A series of eight novel 5-substituted derivatives of benzimidazole was synthesized by condensation of the corresponding diamine with ethyl 4-[4-(2-chlorophenyl)piperazin-1-yl]butanoate in refluxing 4 M hydrochloric acid. In vitro antibacterial activity against ten strains, namely Bacillus subtilis, Clostridium sporogenes, Streptosporangium longisporum, Micrococcus flavus, Sarcina lutea, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris and antifungal activity against two fungal strains, namely Candida albicans and Saccharomyces cerevisiae, were evaluated. Of all the compounds screened for activity, 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-iodo-1H-benzimidazole and 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-methyl-1H-benzimidazole were associated with higher antifungal activity than commercial drugs.
TY - JOUR
AU - Vasić, Vesna P.
AU - Penjišević, Jelena
AU - Novaković, Irena
AU - Šukalović, Vladimir
AU - Andrić, Deana
AU - Kostić Rajačić, Slađana
PY - 2014
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1511
AB - A series of eight novel 5-substituted derivatives of benzimidazole was synthesized by condensation of the corresponding diamine with ethyl 4-[4-(2-chlorophenyl)piperazin-1-yl]butanoate in refluxing 4 M hydrochloric acid. In vitro antibacterial activity against ten strains, namely Bacillus subtilis, Clostridium sporogenes, Streptosporangium longisporum, Micrococcus flavus, Sarcina lutea, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris and antifungal activity against two fungal strains, namely Candida albicans and Saccharomyces cerevisiae, were evaluated. Of all the compounds screened for activity, 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-iodo-1H-benzimidazole and 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-methyl-1H-benzimidazole were associated with higher antifungal activity than commercial drugs.
PB - Serbian Chemical Soc, Belgrade
T2 - Journal of the Serbian Chemical Society
T1 - Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole
VL - 79
IS - 3
SP - 277
EP - 282
DO - 10.2298/JSC130418058V
ER -
@article{
author = "Vasić, Vesna P. and Penjišević, Jelena and Novaković, Irena and Šukalović, Vladimir and Andrić, Deana and Kostić Rajačić, Slađana",
year = "2014",
abstract = "A series of eight novel 5-substituted derivatives of benzimidazole was synthesized by condensation of the corresponding diamine with ethyl 4-[4-(2-chlorophenyl)piperazin-1-yl]butanoate in refluxing 4 M hydrochloric acid. In vitro antibacterial activity against ten strains, namely Bacillus subtilis, Clostridium sporogenes, Streptosporangium longisporum, Micrococcus flavus, Sarcina lutea, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris and antifungal activity against two fungal strains, namely Candida albicans and Saccharomyces cerevisiae, were evaluated. Of all the compounds screened for activity, 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-iodo-1H-benzimidazole and 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-methyl-1H-benzimidazole were associated with higher antifungal activity than commercial drugs.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole",
volume = "79",
number = "3",
pages = "277-282",
doi = "10.2298/JSC130418058V"
}
Vasić, V. P., Penjišević, J., Novaković, I., Šukalović, V., Andrić, D.,& Kostić Rajačić, S.. (2014). Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(3), 277-282.
https://doi.org/10.2298/JSC130418058V
Vasić VP, Penjišević J, Novaković I, Šukalović V, Andrić D, Kostić Rajačić S. Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole. in Journal of the Serbian Chemical Society. 2014;79(3):277-282.
doi:10.2298/JSC130418058V .
Vasić, Vesna P., Penjišević, Jelena, Novaković, Irena, Šukalović, Vladimir, Andrić, Deana, Kostić Rajačić, Slađana, "Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole" in Journal of the Serbian Chemical Society, 79, no. 3 (2014):277-282,
https://doi.org/10.2298/JSC130418058V . .
