Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole

2014
Authors
Vasić, Vesna P.Penjišević, Jelena

Novaković, Irena

Šukalović, Vladimir

Andrić, Deana

Kostić Rajačić, Slađana

Article (Published version)
Metadata
Show full item recordAbstract
A series of eight novel 5-substituted derivatives of benzimidazole was synthesized by condensation of the corresponding diamine with ethyl 4-[4-(2-chlorophenyl)piperazin-1-yl]butanoate in refluxing 4 M hydrochloric acid. In vitro antibacterial activity against ten strains, namely Bacillus subtilis, Clostridium sporogenes, Streptosporangium longisporum, Micrococcus flavus, Sarcina lutea, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris and antifungal activity against two fungal strains, namely Candida albicans and Saccharomyces cerevisiae, were evaluated. Of all the compounds screened for activity, 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-iodo-1H-benzimidazole and 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-methyl-1H-benzimidazole were associated with higher antifungal activity than commercial drugs.
Keywords:
arylpiperazines / benzimidazoles / antibacterial activity / antifungal activitySource:
Journal of the Serbian Chemical Society, 2014, 79, 3, 277-282Publisher:
- Serbian Chemical Soc, Belgrade
Funding / projects:
DOI: 10.2298/JSC130418058V
ISSN: 0352-5139
WoS: 000333770600001
Scopus: 2-s2.0-84896935228
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IHTMTY - JOUR AU - Vasić, Vesna P. AU - Penjišević, Jelena AU - Novaković, Irena AU - Šukalović, Vladimir AU - Andrić, Deana AU - Kostić Rajačić, Slađana PY - 2014 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1511 AB - A series of eight novel 5-substituted derivatives of benzimidazole was synthesized by condensation of the corresponding diamine with ethyl 4-[4-(2-chlorophenyl)piperazin-1-yl]butanoate in refluxing 4 M hydrochloric acid. In vitro antibacterial activity against ten strains, namely Bacillus subtilis, Clostridium sporogenes, Streptosporangium longisporum, Micrococcus flavus, Sarcina lutea, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris and antifungal activity against two fungal strains, namely Candida albicans and Saccharomyces cerevisiae, were evaluated. Of all the compounds screened for activity, 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-iodo-1H-benzimidazole and 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-methyl-1H-benzimidazole were associated with higher antifungal activity than commercial drugs. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole VL - 79 IS - 3 SP - 277 EP - 282 DO - 10.2298/JSC130418058V ER -
@article{ author = "Vasić, Vesna P. and Penjišević, Jelena and Novaković, Irena and Šukalović, Vladimir and Andrić, Deana and Kostić Rajačić, Slađana", year = "2014", abstract = "A series of eight novel 5-substituted derivatives of benzimidazole was synthesized by condensation of the corresponding diamine with ethyl 4-[4-(2-chlorophenyl)piperazin-1-yl]butanoate in refluxing 4 M hydrochloric acid. In vitro antibacterial activity against ten strains, namely Bacillus subtilis, Clostridium sporogenes, Streptosporangium longisporum, Micrococcus flavus, Sarcina lutea, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris and antifungal activity against two fungal strains, namely Candida albicans and Saccharomyces cerevisiae, were evaluated. Of all the compounds screened for activity, 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-iodo-1H-benzimidazole and 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-methyl-1H-benzimidazole were associated with higher antifungal activity than commercial drugs.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole", volume = "79", number = "3", pages = "277-282", doi = "10.2298/JSC130418058V" }
Vasić, V. P., Penjišević, J., Novaković, I., Šukalović, V., Andrić, D.,& Kostić Rajačić, S.. (2014). Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 79(3), 277-282. https://doi.org/10.2298/JSC130418058V
Vasić VP, Penjišević J, Novaković I, Šukalović V, Andrić D, Kostić Rajačić S. Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole. in Journal of the Serbian Chemical Society. 2014;79(3):277-282. doi:10.2298/JSC130418058V .
Vasić, Vesna P., Penjišević, Jelena, Novaković, Irena, Šukalović, Vladimir, Andrić, Deana, Kostić Rajačić, Slađana, "Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole" in Journal of the Serbian Chemical Society, 79, no. 3 (2014):277-282, https://doi.org/10.2298/JSC130418058V . .