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dc.creatorFilipovic, Nenad
dc.creatorGrubišić, Sonja
dc.creatorJovanovic, Maja
dc.creatorDulovic, Marija
dc.creatorMarkovic, Ivanka
dc.creatorKlisurić, Olivera
dc.creatorMarinković, Aleksandar D.
dc.creatorMitić, Dragana
dc.creatorAnđelković, Katarina
dc.creatorTodorović, Tamara
dc.date.accessioned2019-01-30T17:40:51Z
dc.date.available2019-01-30T17:40:51Z
dc.date.issued2014
dc.identifier.issn1747-0277
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1498
dc.description.abstractNovel Pd(II) complex with N-heteroaromatic Schiff base ligand, derived from 8-quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL-60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline-based ligands reduce the cell numbers in a dose-dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline-based complexes is predominantly mediated through the induction of apoptotic cell death in HL-60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated.en
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41025/RS//
dc.rightsrestrictedAccess
dc.sourceChemical Biology & Drug Design
dc.subjectapoptosisen
dc.subjectbiological screeningen
dc.subjectchemical structureen
dc.subjectpalladium(II) complexesen
dc.subjectX-ray crystallographyen
dc.titlePalladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКлисуриц, Оливера; Маринковиц, Aлександар; Марковиц, Иванка; Тодоровиц, Тамара; Дуловиц, Марија; Aнђелковиц, Катарина; Филиповиц, Ненад; Грубишић, Соња; Митиц, Драгана; Јовановиц, Маја;
dc.citation.volume84
dc.citation.issue3
dc.citation.spage333
dc.citation.epage341
dc.citation.other84(3): 333-341
dc.citation.rankM22
dc.identifier.pmid24636459
dc.identifier.doi10.1111/cbdd.12322
dc.identifier.rcubConv_2758
dc.identifier.scopus2-s2.0-84905821443
dc.identifier.wos000342978100009
dc.type.versionpublishedVersion


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