Analysis of human exhaled breath in a population of young volunteers

2014
Authors
Zarić, Božidarka
Petrović, Srđan

Bjekic, Milan
Rajic, Ivana
Popović, Aleksandar R.

Đorđević, Dragana

Article (Published version)
Metadata
Show full item recordAbstract
Analysis of volatile organic compounds (VOCs) in human breath can provide information about the current physiological state of an individual, such as clinical conditions and exposure to exogenous pollutants. The blood-borne VOCs present in exhaled breath offer the possibility of exploring physiological and pathological processes in a noninvasive way. However, the field of exhaled breath analysis is still in its infancy. We undertook this study in order to define inter-individual variation and common compounds in breath VOCs of 48 young human volunteers. Alveolar breath samples were analyzed by automated thermal desorption, gas chromatography with flame ionization detector (FID) and electron capture detector (ECD) using SUPELCO standards with 66 compounds. Predominant compounds in the alveolar breath of analyzed subjects are ethylbenzene, 1-ethyl-4-methylbenzene, 1,2,4-trimethylbenzene and 1,3,5-trimethylbenzene (over 50% of the subjects). Isopropyl alcohol, propylene, acetone, ethanol ...were found as well. We detected substituted compounds in exhaled breath.
Keywords:
alveolar breath / volatile organic compounds / exhaled breath condensate / gas chromatographySource:
Archives of Biological Sciences, 2014, 66, 4, 1529-1538Publisher:
- Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd
Projects:
DOI: 10.2298/ABS1404529Z
ISSN: 0354-4664