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dc.creatorNesic, D M
dc.creatorStevanovic, D M
dc.creatorDjelic, M N
dc.creatorMazic, S D
dc.creatorStankovic, J B Trbojevic
dc.creatorSoldatovi, I I
dc.creatorStajić-Trošić, Jasna
dc.creatorStarčević, V. P.
dc.date.accessioned2019-01-30T17:40:17Z
dc.date.available2019-01-30T17:40:17Z
dc.date.issued2014
dc.identifier.issn1842-3582
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1472
dc.description.abstractThe main purpose of this study was to evaluate specifically, ingestive behavior and bloodborne indicators of metabolic status, after daily intracerebroventricular (ICV) ghrelin injections, in rats of different ages. Four age ranges were tested: peripubertal (similar to 38 days), young (similar to 2 months), adult (similar to 7 months) and middle-aged (similar to 11 months). Multiple variables were measured, including body weight (BW), food and water intake (F, WI), and terminal blood levels of triglycerides (Tg), cholesterol (Chol), free fatty acids (FFA) and glucose (Glu). Five daily ICV injections of ghrelin or saline were administered (n = 8/group, 0.15 nmol of ghrelin in 5 mu L) to rats of different ages. After 5 days of treatment, ICV ghrelin resulted in an increased (p LT 0.05) absolute and relative BW, FI, WI and in elevated blood levels of Chol, Tg, and FFA as well, while blood Glu levels were decreased (p LT 0.05) within each of the four age-matched groups. Differences (p LT 0.05) in ghrelin effects over the ages included the following: relative FI was higher in 2 younger groups vs 2 older ones. Relative WI was higher in 2 younger groups vs 2 older ones. Tg, Chol and FFA in the oldest rats, both control and treated, were higher than corresponding values at the other 3 ages. The youngest age group had the lowest Glu after ghrelin.en
dc.publisherInst Materials Physics
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41025/RS//
dc.rightsrestrictedAccess
dc.sourceDigest Journal of Nanomaterials and Biostructures
dc.subjectGhrelinen
dc.subjectappetiteen
dc.subjectMetabolic parametersen
dc.subjectRatsen
dc.subjectAgeingen
dc.titleThe effects of centrally applied ghrelin on appetite and metabolic parameters during agingen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДјелиц, М Н; Стевановиц, Д М; Мазиц, С Д; Станковиц, Ј Б Трбојевиц; Солдатови, И И; Старчевић, В. П.; Стајић Трошић, Јасна; Несиц, Д М;
dc.citation.volume9
dc.citation.issue4
dc.citation.spage1439
dc.citation.epage1449
dc.citation.other9(4): 1439-1449
dc.citation.rankM23
dc.identifier.rcubConv_3257
dc.identifier.scopus2-s2.0-84908327679
dc.identifier.wos000346138800016
dc.type.versionpublishedVersion


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