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Design, synthesis, and characterization of fullerene-peptide-steroid covalent hybrids
dc.creator | Bjelaković, Mira | |
dc.creator | Kop, Tatjana | |
dc.creator | Vajić, Marina | |
dc.creator | Đordevic, Jelena | |
dc.creator | Milić, Dragana | |
dc.date.accessioned | 2019-01-30T17:40:16Z | |
dc.date.available | 2019-01-30T17:40:16Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0040-4020 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1471 | |
dc.description.abstract | The present study reports the synthesis, spectral characterization, self-assembly properties, and preliminary in vitro study of antioxidant capacity of two triple covalent hybrids consisting of fullerene C-60, peptide, and steroidal moiety. Previously synthesized fulleropyrrolidinic acid and pregnenolone were connected by peptide linker using a multistep DCC/DMAP and/or EDC/HOBT esterification/amidation procedure. The hybrids were characterized by comparative analysis of spectroscopic data obtained from FUR, UV-vis, HRMS, and extensive NMR experiments (H-1, C-13, COSY, HSQC, and HMBC). The self-assembling properties and morphology of triads samples prepared by drop-drying method were examined by scanning electron microscopy (SEM). Preliminary in vitro antioxidant activity was studied by Ferrous ion Oxidation-Xylenol orange (FOX) method. | en |
dc.publisher | Oxford : Pergamon-Elsevier Science Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172002/RS// | |
dc.rights | restrictedAccess | |
dc.source | Tetrahedron | |
dc.subject | Fullerene-peptide-steroid hybrids | en |
dc.subject | DCC/DMAP | en |
dc.subject | EDC/HOBT | en |
dc.subject | SEM | en |
dc.subject | Antioxidant activity | en |
dc.title | Design, synthesis, and characterization of fullerene-peptide-steroid covalent hybrids | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Дордевиц, Јелена; Бјелаковић, Мира; Вајиц, Марина; Коп, Татјана; Милиц, Драгана Р; | |
dc.citation.volume | 70 | |
dc.citation.issue | 45 | |
dc.citation.spage | 8564 | |
dc.citation.epage | 8570 | |
dc.citation.other | 70(45): 8564-8570 | |
dc.citation.rank | M22 | |
dc.identifier.doi | 10.1016/j.tet.2014.09.070 | |
dc.identifier.scopus | 2-s2.0-84907971389 | |
dc.identifier.wos | 000345815100015 | |
dc.type.version | publishedVersion |