The present study reports the synthesis, spectral characterization, self-assembly properties, and preliminary in vitro study of antioxidant capacity of two triple covalent hybrids consisting of fullerene C-60, peptide, and steroidal moiety. Previously synthesized fulleropyrrolidinic acid and pregnenolone were connected by peptide linker using a multistep DCC/DMAP and/or EDC/HOBT esterification/amidation procedure. The hybrids were characterized by comparative analysis of spectroscopic data obtained from FUR, UV-vis, HRMS, and extensive NMR experiments (H-1, C-13, COSY, HSQC, and HMBC). The self-assembling properties and morphology of triads samples prepared by drop-drying method were examined by scanning electron microscopy (SEM). Preliminary in vitro antioxidant activity was studied by Ferrous ion Oxidation-Xylenol orange (FOX) method.
TY - JOUR
AU - Bjelaković, Mira
AU - Kop, Tatjana
AU - Vajic, Marina
AU - Dordevic, Jelena
AU - Milić, Dragana
PY - 2014
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1471
AB - The present study reports the synthesis, spectral characterization, self-assembly properties, and preliminary in vitro study of antioxidant capacity of two triple covalent hybrids consisting of fullerene C-60, peptide, and steroidal moiety. Previously synthesized fulleropyrrolidinic acid and pregnenolone were connected by peptide linker using a multistep DCC/DMAP and/or EDC/HOBT esterification/amidation procedure. The hybrids were characterized by comparative analysis of spectroscopic data obtained from FUR, UV-vis, HRMS, and extensive NMR experiments (H-1, C-13, COSY, HSQC, and HMBC). The self-assembling properties and morphology of triads samples prepared by drop-drying method were examined by scanning electron microscopy (SEM). Preliminary in vitro antioxidant activity was studied by Ferrous ion Oxidation-Xylenol orange (FOX) method.
PB - Oxford : Pergamon-Elsevier Science Ltd
T2 - Tetrahedron
T1 - Design, synthesis, and characterization of fullerene-peptide-steroid covalent hybrids
VL - 70
IS - 45
SP - 8564
EP - 8570
DO - 10.1016/j.tet.2014.09.070
ER -
@article{
author = "Bjelaković, Mira and Kop, Tatjana and Vajic, Marina and Dordevic, Jelena and Milić, Dragana",
year = "2014",
abstract = "The present study reports the synthesis, spectral characterization, self-assembly properties, and preliminary in vitro study of antioxidant capacity of two triple covalent hybrids consisting of fullerene C-60, peptide, and steroidal moiety. Previously synthesized fulleropyrrolidinic acid and pregnenolone were connected by peptide linker using a multistep DCC/DMAP and/or EDC/HOBT esterification/amidation procedure. The hybrids were characterized by comparative analysis of spectroscopic data obtained from FUR, UV-vis, HRMS, and extensive NMR experiments (H-1, C-13, COSY, HSQC, and HMBC). The self-assembling properties and morphology of triads samples prepared by drop-drying method were examined by scanning electron microscopy (SEM). Preliminary in vitro antioxidant activity was studied by Ferrous ion Oxidation-Xylenol orange (FOX) method.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Tetrahedron",
title = "Design, synthesis, and characterization of fullerene-peptide-steroid covalent hybrids",
volume = "70",
number = "45",
pages = "8564-8570",
doi = "10.1016/j.tet.2014.09.070"
}
Bjelaković, M., Kop, T., Vajic, M., Dordevic, J.,& Milić, D.. (2014). Design, synthesis, and characterization of fullerene-peptide-steroid covalent hybrids. in Tetrahedron
Oxford : Pergamon-Elsevier Science Ltd., 70(45), 8564-8570.
https://doi.org/10.1016/j.tet.2014.09.070
Bjelaković M, Kop T, Vajic M, Dordevic J, Milić D. Design, synthesis, and characterization of fullerene-peptide-steroid covalent hybrids. in Tetrahedron. 2014;70(45):8564-8570.
doi:10.1016/j.tet.2014.09.070 .
Bjelaković, Mira, Kop, Tatjana, Vajic, Marina, Dordevic, Jelena, Milić, Dragana, "Design, synthesis, and characterization of fullerene-peptide-steroid covalent hybrids" in Tetrahedron, 70, no. 45 (2014):8564-8570,
https://doi.org/10.1016/j.tet.2014.09.070 . .
