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Synthesis, characterization, DFT calculation and biological activity of square-planar Ni(II) complexes with tridentate PNO ligands and monodentate pseudohalides. Part II

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2014
Authors
Milenković, Milica R.
Pevec, Andrej
Turel, Iztok
Vujčić, Miroslava
Milenković, Marina
Jovanovic, Katarina
Gligorijević, Nevenka
Radulovic, Sinisa
Swart, Marcel
Gruden-Pavlović, Maja
Adaila, Kawther
Čobeljić, Božidar
Anđelković, Katarina
Article (Published version)
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Abstract
Three square-planar complexes of Ni(II) with condensation derivative of 2-(diphenylphosphino)benzaldehyde and 4-phenylsemicarbazide and monodentate pseudohalides have been synthesized and characterized on the basis of the results of X-ray. NMR and IR spectroscopy and elemental analysis. Investigated complexes exhibited moderate antibacterial and cytotoxic activity. The most pronounced cytotoxic activity (in the range of cisplatin) to HeLa cell line was observed for ligand and all the complexes. Azido complex and ligand induced concentration dependent cell cycle arrest in the S phase, as well as decrease of percentage of cells in G1 phase, without significant increase of apoptotic fraction of cells. The interaction of the azido complex and ligand with CT-DNA results in changes in UV-Vis spectra typical for non-covalent bonding. The observed intrinsic binding constant of azido complex CT-DNA and ligand-CT-DNA were 3.22 x 10(5) M-1 and 2.79 x 10(5) M-1. The results of DNA cleavage experim...ents showed that azido complex nicked supercoiled plasmid DNA.

Keywords:
Nickel(II) complexes / Pseudohalides / X-ray crystal structures / Antimicrobial activity / cytotoxicity
Source:
European Journal of Medicinal Chemistry, 2014, 87, 284-297
Publisher:
  • Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
Projects:
  • Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
  • Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-41026)
  • ICREA
  • Slovenian Research Agency (ARRS) [P-0175]

DOI: 10.1016/j.ejmech.2014.06.079

ISSN: 0223-5234

PubMed: 25262049

WoS: 000363431300027

Scopus: 2-s2.0-84907517896
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14
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1464
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