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dc.creatorBajcetic, Milica
dc.creatorSpasić, Snežana
dc.creatorSpasojević, Ivan
dc.date.accessioned2019-01-30T17:39:35Z
dc.date.available2019-01-30T17:39:35Z
dc.date.issued2014
dc.identifier.issn1073-2322
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/1433
dc.identifier.urihttps://journals.lww.com/shockjournal/Fulltext/2014/09000/Redox_Therapy_in_Neonatal_Sepsis___Reasons,.2.aspx#pdf-link
dc.description.abstractNeonatal sepsis is one of the most fulminating conditions in neonatal intensive care units. Antipathogen and supportive care are administered routinely, but do not deliver satisfactory results. In addition, the efforts to treat neonatal sepsis with anti-inflammatory agents have generally shown to be futile. The accumulating data imply that intracellular redox changes intertwined into neonatal sepsis redox cycle represent the main cause of dysfunction of mitochondria and cells in neonatal sepsis. Our aim here is to support the new philosophy in neonatal sepsis treatment, which involves the integration of mechanisms that are responsible for cellular dysfunction and organ failure, the recognition of the most important targets, and the selection of safe agents that can stop the neonatal sepsis redox cycle by hitting the hot spots. Redox-active agents that could be beneficial for neonatal sepsis treatment according to these criteria include lactoferrin, interleukin 10, zinc and selenium supplements, ibuprofen, edaravone, and pentoxifylline.en
dc.publisherLippincott Williams & Wilkins, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS//
dc.rightsopenAccess
dc.sourceShock
dc.subjectAntioxidantsen
dc.subjectmitochondriaen
dc.subjectneonateen
dc.subjectoxidative stressen
dc.subjectsepsisen
dc.titleRedox therapy in neonatal sepsis: reasons, targets, strategy, and agentsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСпасојевиц, Иван; Бајцетиц, Милица; Спасић, Снежана;
dc.citation.volume42
dc.citation.issue3
dc.citation.spage179
dc.citation.epage184
dc.citation.other42(3): 179-184
dc.citation.rankM21
dc.identifier.pmid24827393
dc.identifier.doi10.1097/SHK.0000000000000198
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs/bitstream/id/14092/Redox_Therapy_in_Neonatal_Sepsis.pdf
dc.identifier.scopus2-s2.0-85027930403
dc.identifier.wos000341494400002
dc.type.versionpublishedVersion


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