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Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents

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2014
Redox_Therapy_in_Neonatal_Sepsis.pdf (2.637Mb)
Аутори
Bajcetic, Milica
Spasić, Snežana
Spasojević, Ivan
Чланак у часопису (Објављена верзија)
Метаподаци
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Апстракт
Neonatal sepsis is one of the most fulminating conditions in neonatal intensive care units. Antipathogen and supportive care are administered routinely, but do not deliver satisfactory results. In addition, the efforts to treat neonatal sepsis with anti-inflammatory agents have generally shown to be futile. The accumulating data imply that intracellular redox changes intertwined into neonatal sepsis redox cycle represent the main cause of dysfunction of mitochondria and cells in neonatal sepsis. Our aim here is to support the new philosophy in neonatal sepsis treatment, which involves the integration of mechanisms that are responsible for cellular dysfunction and organ failure, the recognition of the most important targets, and the selection of safe agents that can stop the neonatal sepsis redox cycle by hitting the hot spots. Redox-active agents that could be beneficial for neonatal sepsis treatment according to these criteria include lactoferrin, interleukin 10, zinc and selenium sup...plements, ibuprofen, edaravone, and pentoxifylline.

Кључне речи:
Antioxidants / mitochondria / neonate / oxidative stress / sepsis
Извор:
Shock, 2014, 42, 3, 179-184
Издавач:
  • Lippincott Williams & Wilkins, Philadelphia
Финансирање / пројекти:
  • Молекуларни механизми редокс сигналинга у хомеостази, адаптацији и патологији (RS-173014)
  • Симултана биоремедијација и соилификација деградираних простора, за очување природних ресурса биолошки активних супстанци и развој и производњу биоматеријала и дијететских производа (RS-43004)

DOI: 10.1097/SHK.0000000000000198

ISSN: 1073-2322

PubMed: 24827393

WoS: 000341494400002

Scopus: 2-s2.0-85027930403
[ Google Scholar ]
21
19
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/1433
https://journals.lww.com/shockjournal/Fulltext/2014/09000/Redox_Therapy_in_Neonatal_Sepsis___Reasons,.2.aspx#pdf-link
Колекције
  • Radovi istraživača / Researchers' publications
Институција/група
IHTM
TY  - JOUR
AU  - Bajcetic, Milica
AU  - Spasić, Snežana
AU  - Spasojević, Ivan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1433
UR  - https://journals.lww.com/shockjournal/Fulltext/2014/09000/Redox_Therapy_in_Neonatal_Sepsis___Reasons,.2.aspx#pdf-link
AB  - Neonatal sepsis is one of the most fulminating conditions in neonatal intensive care units. Antipathogen and supportive care are administered routinely, but do not deliver satisfactory results. In addition, the efforts to treat neonatal sepsis with anti-inflammatory agents have generally shown to be futile. The accumulating data imply that intracellular redox changes intertwined into neonatal sepsis redox cycle represent the main cause of dysfunction of mitochondria and cells in neonatal sepsis. Our aim here is to support the new philosophy in neonatal sepsis treatment, which involves the integration of mechanisms that are responsible for cellular dysfunction and organ failure, the recognition of the most important targets, and the selection of safe agents that can stop the neonatal sepsis redox cycle by hitting the hot spots. Redox-active agents that could be beneficial for neonatal sepsis treatment according to these criteria include lactoferrin, interleukin 10, zinc and selenium supplements, ibuprofen, edaravone, and pentoxifylline.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Shock
T1  - Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents
VL  - 42
IS  - 3
SP  - 179
EP  - 184
DO  - 10.1097/SHK.0000000000000198
ER  - 
@article{
author = "Bajcetic, Milica and Spasić, Snežana and Spasojević, Ivan",
year = "2014",
abstract = "Neonatal sepsis is one of the most fulminating conditions in neonatal intensive care units. Antipathogen and supportive care are administered routinely, but do not deliver satisfactory results. In addition, the efforts to treat neonatal sepsis with anti-inflammatory agents have generally shown to be futile. The accumulating data imply that intracellular redox changes intertwined into neonatal sepsis redox cycle represent the main cause of dysfunction of mitochondria and cells in neonatal sepsis. Our aim here is to support the new philosophy in neonatal sepsis treatment, which involves the integration of mechanisms that are responsible for cellular dysfunction and organ failure, the recognition of the most important targets, and the selection of safe agents that can stop the neonatal sepsis redox cycle by hitting the hot spots. Redox-active agents that could be beneficial for neonatal sepsis treatment according to these criteria include lactoferrin, interleukin 10, zinc and selenium supplements, ibuprofen, edaravone, and pentoxifylline.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Shock",
title = "Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents",
volume = "42",
number = "3",
pages = "179-184",
doi = "10.1097/SHK.0000000000000198"
}
Bajcetic, M., Spasić, S.,& Spasojević, I.. (2014). Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents. in Shock
Lippincott Williams & Wilkins, Philadelphia., 42(3), 179-184.
https://doi.org/10.1097/SHK.0000000000000198
Bajcetic M, Spasić S, Spasojević I. Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents. in Shock. 2014;42(3):179-184.
doi:10.1097/SHK.0000000000000198 .
Bajcetic, Milica, Spasić, Snežana, Spasojević, Ivan, "Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents" in Shock, 42, no. 3 (2014):179-184,
https://doi.org/10.1097/SHK.0000000000000198 . .

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