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dc.creatorKaluđerović, Goran N.
dc.creatorPantelić, Nebojša Đ.
dc.creatorEichhorn, Thomas
dc.creatorBette, Martin
dc.creatorWagner, Christoph
dc.creatorZmejkovski, Bojana
dc.creatorSchmidt, Harry
dc.date.accessioned2019-01-30T17:39:23Z
dc.date.available2019-01-30T17:39:23Z
dc.date.issued2014
dc.identifier.issn0277-5387
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1424
dc.description.abstractThree novel complexes of platinum(II) with R(2)edda bidentate ligands [PtCl2(R(2)edda)] (R = Me, Et, n-Pr; edda = ethylenediamine-N,N'-diacetate; 1-3), are synthesized and characterized by IR and NMR spectroscopy and elemental analysis. All complexes exist in three stereoisomeric forms (R,R), (S,S) and (R,S)(S,R). In addition crystal structure of one platinum(IV) complex [PtCl4((n-Pr)(2)edda)], 4, is presented. Furthermore, in order to assign stereoisomers of 1-3, a reduction of racemic [PtCl4(Et(2)edda)] by ascorbic acid to [PtCl2(Et(2)edda)] (2) was performed and analyzed by H-1 NMR. Time-depending H-1 NMR spectroscopic experiments were implemented to study the stability of ethylenediamine-N,N'-diacetate diesters. Finally, the in vitro cytotoxic activity of complexes 1-3 was studied on 11 tumor cell lines, 518A2 (melanoma), 8505C (human thyroid carcinoma), A253 (head and neck tumor), A431 (cervix), A549 (lung), A2780 (ovarian), MCF-7 (breast) and HT-29, HCT-8, DLD-1, SW1736 (all colon) by the SRB colorimetric assay method. Complex 3 showed the highest action against ovarian (A2780) cells with an IC50 value 51 +/- 1 mu M.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationAlexander von Humboldt Foundation (Germany)
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.rightsrestrictedAccess
dc.sourcePolyhedron
dc.subjectPlatinum(II) complexesen
dc.subjectPlatinum(IV) complexesen
dc.subjectR(2)edda-type ligandsen
dc.subjectDiastereoisomersen
dc.subjectCrystal structureen
dc.subjectcytotoxic activityen
dc.titlePlatinum(II) complexes with R(2)edda ligands (R = Me, Et, n-Pr; edda = ethylenediamine-N,N '-diacetate): Synthesis and characterizationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗмејковски, Бојана; Бетте, Мартин; Wагнер, Цхристопх; Калудеровиц, Горан Н; Еицххорн, Тхомас; Сцхмидт, Харрy; Пантелиц, Небојса;
dc.citation.volume80
dc.citation.spage53
dc.citation.epage59
dc.citation.other80: 53-59
dc.citation.rankM22
dc.identifier.doi10.1016/j.poly.2014.01.018
dc.identifier.rcubConv_3207
dc.identifier.scopus2-s2.0-84905502683
dc.identifier.wos000341348300008
dc.type.versionpublishedVersion


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