Show simple item record

dc.creatorTodosijević, Marija
dc.creatorCekic, Nebojsa
dc.creatorSavić, Miroslav M.
dc.creatorGasperlin, Mirjana
dc.creatorRanđelović, Danijela
dc.creatorSavić, Snežana D.
dc.date.accessioned2019-01-30T17:39:04Z
dc.date.available2019-01-30T17:39:04Z
dc.date.issued2014
dc.identifier.issn0303-402X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1411
dc.description.abstractWe assessed the functionality of sucrose esters (sucrose laurate, myristate, palmitate, and stearate), relatively innocuous nonionic surfactants, in formulation of biocompatible microemulsions. The putative influence of surfactant structure on the extension of microemulsion region was explored through the construction of the pseudo-ternary phase diagrams for the isopropyl myristate/sucrose ester-isopropyl alcohol/water system, using the titration method and mixture experimental approach. Minor changes in surfactant tail length strongly affected the microemulsion area boundaries. D-optimal mixture design proved to be highly applicable in detecting the microemulsion regions. Examination of conductivity, rheology, and thermal behavior of the selected sucrose laurate and sucrose myristate-based microemulsions, upon dilution with water, indicated existence of percolation threshold and suggested the phase inversion from water-in-oil to oil-in-water via a bicontinuous structure. Atomic force micrographs confirmed the suggested type of microemulsions and were valuable in further exploring their inner structure. The solubilization capacity of aceclofenac as a model drug has decreased as the water volume fraction in microemulsion increased. High surfactant concentration and the measured solubility of aceclofenac in microemulsion components suggested that the interfacial film may mostly contribute to aceclofenac solubilization.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/32008/RS//
dc.rightsrestrictedAccess
dc.sourceColloid and Polymer Science
dc.subjectBiocompatible sucrose esteren
dc.subjectMicroemulsionen
dc.subjectD-optimal mixture designen
dc.subjectAtomic force microscopyen
dc.subjectAceclofenacen
dc.titleSucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture designen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТодосијевиц, Марија Н; Гасперлин, Мирјана; Цекиц, Небојса Д; Савиц, Мирослав М; Савиц, Снезана Д; Ранђеловић, Данијела;
dc.citation.volume292
dc.citation.issue12
dc.citation.spage3061
dc.citation.epage3076
dc.citation.other292(12): 3061-3076
dc.citation.rankM22
dc.identifier.doi10.1007/s00396-014-3351-4
dc.identifier.rcubConv_3246
dc.identifier.scopus2-s2.0-84920249616
dc.identifier.wos000344880000001
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record