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Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design

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2014
Authors
Todosijević, Marija
Cekic, Nebojsa
Savić, Miroslav M.
Gasperlin, Mirjana
Ranđelović, Danijela
Savić, Snežana D.
Article (Published version)
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Abstract
We assessed the functionality of sucrose esters (sucrose laurate, myristate, palmitate, and stearate), relatively innocuous nonionic surfactants, in formulation of biocompatible microemulsions. The putative influence of surfactant structure on the extension of microemulsion region was explored through the construction of the pseudo-ternary phase diagrams for the isopropyl myristate/sucrose ester-isopropyl alcohol/water system, using the titration method and mixture experimental approach. Minor changes in surfactant tail length strongly affected the microemulsion area boundaries. D-optimal mixture design proved to be highly applicable in detecting the microemulsion regions. Examination of conductivity, rheology, and thermal behavior of the selected sucrose laurate and sucrose myristate-based microemulsions, upon dilution with water, indicated existence of percolation threshold and suggested the phase inversion from water-in-oil to oil-in-water via a bicontinuous structure. Atomic force ...micrographs confirmed the suggested type of microemulsions and were valuable in further exploring their inner structure. The solubilization capacity of aceclofenac as a model drug has decreased as the water volume fraction in microemulsion increased. High surfactant concentration and the measured solubility of aceclofenac in microemulsion components suggested that the interfacial film may mostly contribute to aceclofenac solubilization.

Keywords:
Biocompatible sucrose ester / Microemulsion / D-optimal mixture design / Atomic force microscopy / Aceclofenac
Source:
Colloid and Polymer Science, 2014, 292, 12, 3061-3076
Publisher:
  • Springer, New York
Projects:
  • Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)
  • Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)

DOI: 10.1007/s00396-014-3351-4

ISSN: 0303-402X

WoS: 000344880000001

Scopus: 2-s2.0-84920249616
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14
15
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1411
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