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Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design

Authorized Users Only
2014
Authors
Todosijević, Marija
Cekic, Nebojsa
Savić, Miroslav M.
Gasperlin, Mirjana
Randjelović, Danijela
Savić, Snežana D.
Article (Published version)
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Abstract
We assessed the functionality of sucrose esters (sucrose laurate, myristate, palmitate, and stearate), relatively innocuous nonionic surfactants, in formulation of biocompatible microemulsions. The putative influence of surfactant structure on the extension of microemulsion region was explored through the construction of the pseudo-ternary phase diagrams for the isopropyl myristate/sucrose ester-isopropyl alcohol/water system, using the titration method and mixture experimental approach. Minor changes in surfactant tail length strongly affected the microemulsion area boundaries. D-optimal mixture design proved to be highly applicable in detecting the microemulsion regions. Examination of conductivity, rheology, and thermal behavior of the selected sucrose laurate and sucrose myristate-based microemulsions, upon dilution with water, indicated existence of percolation threshold and suggested the phase inversion from water-in-oil to oil-in-water via a bicontinuous structure. Atomic force ...micrographs confirmed the suggested type of microemulsions and were valuable in further exploring their inner structure. The solubilization capacity of aceclofenac as a model drug has decreased as the water volume fraction in microemulsion increased. High surfactant concentration and the measured solubility of aceclofenac in microemulsion components suggested that the interfacial film may mostly contribute to aceclofenac solubilization.

Keywords:
Biocompatible sucrose ester / Microemulsion / D-optimal mixture design / Atomic force microscopy / Aceclofenac
Source:
Colloid and Polymer Science, 2014, 292, 12, 3061-3076
Publisher:
  • Springer, New York
Funding / projects:
  • Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)
  • Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)

DOI: 10.1007/s00396-014-3351-4

ISSN: 0303-402X

WoS: 000344880000001

Scopus: 2-s2.0-84920249616
[ Google Scholar ]
17
17
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/1411
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Todosijević, Marija
AU  - Cekic, Nebojsa
AU  - Savić, Miroslav M.
AU  - Gasperlin, Mirjana
AU  - Randjelović, Danijela
AU  - Savić, Snežana D.
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1411
AB  - We assessed the functionality of sucrose esters (sucrose laurate, myristate, palmitate, and stearate), relatively innocuous nonionic surfactants, in formulation of biocompatible microemulsions. The putative influence of surfactant structure on the extension of microemulsion region was explored through the construction of the pseudo-ternary phase diagrams for the isopropyl myristate/sucrose ester-isopropyl alcohol/water system, using the titration method and mixture experimental approach. Minor changes in surfactant tail length strongly affected the microemulsion area boundaries. D-optimal mixture design proved to be highly applicable in detecting the microemulsion regions. Examination of conductivity, rheology, and thermal behavior of the selected sucrose laurate and sucrose myristate-based microemulsions, upon dilution with water, indicated existence of percolation threshold and suggested the phase inversion from water-in-oil to oil-in-water via a bicontinuous structure. Atomic force micrographs confirmed the suggested type of microemulsions and were valuable in further exploring their inner structure. The solubilization capacity of aceclofenac as a model drug has decreased as the water volume fraction in microemulsion increased. High surfactant concentration and the measured solubility of aceclofenac in microemulsion components suggested that the interfacial film may mostly contribute to aceclofenac solubilization.
PB  - Springer, New York
T2  - Colloid and Polymer Science
T1  - Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design
VL  - 292
IS  - 12
SP  - 3061
EP  - 3076
DO  - 10.1007/s00396-014-3351-4
ER  - 
@article{
author = "Todosijević, Marija and Cekic, Nebojsa and Savić, Miroslav M. and Gasperlin, Mirjana and Randjelović, Danijela and Savić, Snežana D.",
year = "2014",
abstract = "We assessed the functionality of sucrose esters (sucrose laurate, myristate, palmitate, and stearate), relatively innocuous nonionic surfactants, in formulation of biocompatible microemulsions. The putative influence of surfactant structure on the extension of microemulsion region was explored through the construction of the pseudo-ternary phase diagrams for the isopropyl myristate/sucrose ester-isopropyl alcohol/water system, using the titration method and mixture experimental approach. Minor changes in surfactant tail length strongly affected the microemulsion area boundaries. D-optimal mixture design proved to be highly applicable in detecting the microemulsion regions. Examination of conductivity, rheology, and thermal behavior of the selected sucrose laurate and sucrose myristate-based microemulsions, upon dilution with water, indicated existence of percolation threshold and suggested the phase inversion from water-in-oil to oil-in-water via a bicontinuous structure. Atomic force micrographs confirmed the suggested type of microemulsions and were valuable in further exploring their inner structure. The solubilization capacity of aceclofenac as a model drug has decreased as the water volume fraction in microemulsion increased. High surfactant concentration and the measured solubility of aceclofenac in microemulsion components suggested that the interfacial film may mostly contribute to aceclofenac solubilization.",
publisher = "Springer, New York",
journal = "Colloid and Polymer Science",
title = "Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design",
volume = "292",
number = "12",
pages = "3061-3076",
doi = "10.1007/s00396-014-3351-4"
}
Todosijević, M., Cekic, N., Savić, M. M., Gasperlin, M., Randjelović, D.,& Savić, S. D.. (2014). Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design. in Colloid and Polymer Science
Springer, New York., 292(12), 3061-3076.
https://doi.org/10.1007/s00396-014-3351-4
Todosijević M, Cekic N, Savić MM, Gasperlin M, Randjelović D, Savić SD. Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design. in Colloid and Polymer Science. 2014;292(12):3061-3076.
doi:10.1007/s00396-014-3351-4 .
Todosijević, Marija, Cekic, Nebojsa, Savić, Miroslav M., Gasperlin, Mirjana, Randjelović, Danijela, Savić, Snežana D., "Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design" in Colloid and Polymer Science, 292, no. 12 (2014):3061-3076,
https://doi.org/10.1007/s00396-014-3351-4 . .

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