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Antimalarijska aktivnost derivata 7,8,15,16-tetraoksa-dispiro5.2.5.2heksadekan-3-karboksilne kiseline

dc.creatorOpsenica, Igor
dc.creatorTerzić-Jovanović, Nataša
dc.creatorOpsenica, Dejan
dc.creatorMilhous, Wilbur K.
dc.creatorŠolaja, Bogdan
dc.date.accessioned2019-01-30T17:11:57Z
dc.date.available2019-01-30T17:11:57Z
dc.date.issued2004
dc.identifier.issn0352-5139
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/140
dc.description.abstractSeveral C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š5.2.5.2Ćhexadecane-3-carboxamide being as active as artemisinin.en
dc.description.abstractU ovom radu prikazana je sinteza serije C2 mešovitih tetraoksana polazeći od gem-dihidroperoksida cikloheksanona. Dobijenim derivatima ispitana je in vitro aktivnost prema W2 i D6 sojevima P. falciparum. Utvrđeno je da derivat N-(2-dimetilamino)etil 7,8,15,16-tetraoksa-dispiroŠ5.2.5.2Ćheksadekan-3-karboksamid pokazuje aktivnost vrlo blisku aktivnosti poznatog antimalarika artemizinina.sr
dc.publisherSerbian Chemical Society
dc.relationProject MESTD, br. 1579
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectmixed tetraoxaneen
dc.subjectmalariaen
dc.subjectPlasmodium falciparumen
dc.subjectgem-dihydroperoxideen
dc.title7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activityen
dc.titleAntimalarijska aktivnost derivata 7,8,15,16-tetraoksa-dispiro5.2.5.2heksadekan-3-karboksilne kiselinesr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractОпсеница, Игор; Терзић Јовановић, Наташа; Опсеница, Дејан; Милхоус, Wилбур К.; Шолаја, Богдан A.; Aнтималаријска активност деривата 7,8,15,16-тетраокса-диспиро5.2.5.2хексадекан-3-карбоксилне киселине; Aнтималаријска активност деривата 7,8,15,16-тетраокса-диспиро5.2.5.2хексадекан-3-карбоксилне киселине;
dc.citation.volume69
dc.citation.issue11
dc.citation.spage919
dc.citation.epage922
dc.citation.other69(11): 919-922
dc.citation.rankM23
dc.citation.rankM23
dc.identifier.doi10.2298/JSC0411919O
dc.identifier.rcubConv_191
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/7873/138.pdf
dc.identifier.scopus2-s2.0-31544476296
dc.identifier.wos000226120300011
dc.type.versionpublishedVersion


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