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Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C
dc.creator | Matović, Radomir | |
dc.creator | Bihelović, Filip | |
dc.creator | Gruden-Pavlović, Maja | |
dc.creator | Saičić, Radomir N. | |
dc.date.accessioned | 2019-01-30T17:38:50Z | |
dc.date.available | 2019-01-30T17:38:50Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1477-0520 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1400 | |
dc.description.abstract | The total synthesis of desmethylabyssomicin C analogue 1 was accomplished using diastereotopos-selective ring closing metathesis and Nozaki-Hiyama-Kishi cyclization as the key steps. The synthetic analogue retained its antibacterial activity against methicillin-resistant S. aureus strains, whereas its cytotoxicity decreased for three orders of magnitude, as compared to atrop-abyssomicin C. | en |
dc.publisher | Royal Soc Chemistry, Cambridge | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172027/RS// | |
dc.relation | Serbian Academy of Sciences and Arts [F193] | |
dc.rights | restrictedAccess | |
dc.source | Organic & Biomolecular Chemistry | |
dc.title | Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Саициц, Р Н; Груден-Павловић, Маја; Матовић, Радомир; Бихеловиц, Ф; | |
dc.citation.volume | 12 | |
dc.citation.issue | 39 | |
dc.citation.spage | 7682 | |
dc.citation.epage | 7685 | |
dc.citation.other | 12(39): 7682-7685 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 25166901 | |
dc.identifier.doi | 10.1039/c4ob01436g | |
dc.identifier.scopus | 2-s2.0-84907867681 | |
dc.identifier.wos | 000342886000005 | |
dc.type.version | publishedVersion |