7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity
Antimalarijska aktivnost derivata 7,8,15,16-tetraoksa-dispiro5.2.5.2heksadekan-3-karboksilne kiseline
Апстракт
Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š5.2.5.2Ćhexadecane-3-carboxamide being as active as artemisinin.
U ovom radu prikazana je sinteza serije C2 mešovitih tetraoksana polazeći od gem-dihidroperoksida cikloheksanona. Dobijenim derivatima ispitana je in vitro aktivnost prema W2 i D6 sojevima P. falciparum. Utvrđeno je da derivat N-(2-dimetilamino)etil 7,8,15,16-tetraoksa-dispiroŠ5.2.5.2Ćheksadekan-3-karboksamid pokazuje aktivnost vrlo blisku aktivnosti poznatog antimalarika artemizinina.
Кључне речи:
mixed tetraoxane / malaria / Plasmodium falciparum / gem-dihydroperoxideИзвор:
Journal of the Serbian Chemical Society, 2004, 69, 11, 919-922Издавач:
- Serbian Chemical Society
Финансирање / пројекти:
- Project MESTD, br. 1579
DOI: 10.2298/JSC0411919O
ISSN: 0352-5139
WoS: 000226120300011
Scopus: 2-s2.0-31544476296
Институција/група
IHTMTY - JOUR AU - Opsenica, Igor AU - Terzić-Jovanović, Nataša AU - Opsenica, Dejan AU - Milhous, Wilbur K. AU - Šolaja, Bogdan PY - 2004 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/140 AB - Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š5.2.5.2Ćhexadecane-3-carboxamide being as active as artemisinin. AB - U ovom radu prikazana je sinteza serije C2 mešovitih tetraoksana polazeći od gem-dihidroperoksida cikloheksanona. Dobijenim derivatima ispitana je in vitro aktivnost prema W2 i D6 sojevima P. falciparum. Utvrđeno je da derivat N-(2-dimetilamino)etil 7,8,15,16-tetraoksa-dispiroŠ5.2.5.2Ćheksadekan-3-karboksamid pokazuje aktivnost vrlo blisku aktivnosti poznatog antimalarika artemizinina. PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity T1 - Antimalarijska aktivnost derivata 7,8,15,16-tetraoksa-dispiro5.2.5.2heksadekan-3-karboksilne kiseline VL - 69 IS - 11 SP - 919 EP - 922 DO - 10.2298/JSC0411919O ER -
@article{ author = "Opsenica, Igor and Terzić-Jovanović, Nataša and Opsenica, Dejan and Milhous, Wilbur K. and Šolaja, Bogdan", year = "2004", abstract = "Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š5.2.5.2Ćhexadecane-3-carboxamide being as active as artemisinin., U ovom radu prikazana je sinteza serije C2 mešovitih tetraoksana polazeći od gem-dihidroperoksida cikloheksanona. Dobijenim derivatima ispitana je in vitro aktivnost prema W2 i D6 sojevima P. falciparum. Utvrđeno je da derivat N-(2-dimetilamino)etil 7,8,15,16-tetraoksa-dispiroŠ5.2.5.2Ćheksadekan-3-karboksamid pokazuje aktivnost vrlo blisku aktivnosti poznatog antimalarika artemizinina.", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity, Antimalarijska aktivnost derivata 7,8,15,16-tetraoksa-dispiro5.2.5.2heksadekan-3-karboksilne kiseline", volume = "69", number = "11", pages = "919-922", doi = "10.2298/JSC0411919O" }
Opsenica, I., Terzić-Jovanović, N., Opsenica, D., Milhous, W. K.,& Šolaja, B.. (2004). 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity. in Journal of the Serbian Chemical Society Serbian Chemical Society., 69(11), 919-922. https://doi.org/10.2298/JSC0411919O
Opsenica I, Terzić-Jovanović N, Opsenica D, Milhous WK, Šolaja B. 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity. in Journal of the Serbian Chemical Society. 2004;69(11):919-922. doi:10.2298/JSC0411919O .
Opsenica, Igor, Terzić-Jovanović, Nataša, Opsenica, Dejan, Milhous, Wilbur K., Šolaja, Bogdan, "7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity" in Journal of the Serbian Chemical Society, 69, no. 11 (2004):919-922, https://doi.org/10.2298/JSC0411919O . .