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dc.creatorPergal, Marija
dc.creatorNestorov, Jelena
dc.creatorTovilović, Gordana
dc.creatorOstojić, Sanja
dc.creatorGođevac, Dejan
dc.creatorVasiljević-Radović, Dana
dc.creatorĐonlagić, Jasna
dc.date.accessioned2019-01-30T17:38:48Z
dc.date.available2019-01-30T17:38:48Z
dc.date.issued2014
dc.identifier.issn1549-3296
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/1398
dc.description.abstractProperties and biocompatibility of a series of thermoplastic poly(urethane-siloxane)s (TPUSs) based on alpha,omega-dihydroxy ethoxy propyl poly(dimethylsiloxane) (PDMS) for potential biomedical application were studied. Thin films of TPUSs with a different PDMS soft segment content were characterized by H-1 NMR, quantitative C-13 NMR, Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), contact angle, and water absorption measurements. Different techniques (FTIR, AFM, and DMA) showed that decrease of PDMS content promotes microphase separation in TPUSs. Samples with a higher PDMS content have more hydrophobic surface and better waterproof performances, but lower degree of crystallinity. Biocompatibility of TPUSs was examined after attachment of endothelial cells to the untreated copolymer surface or surface pretreated with multicomponent protein mixture, and by using competitive protein adsorption assay. TPUSs did not exhibit any cytotoxicity toward endothelial cells, as measured by lactate dehydrogenase and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide assays. The untreated and proteins preadsorbed TPUS samples favored endothelial cells adhesion and growth, indicating good biocompatibility. All TPUSs adsorbed more albumin than fibrinogen in competitive protein adsorption experiment, which is feature regarded as beneficial for biocompatibility. The results indicate that TPUSs have good surface, thermo-mechanical, and biocompatible properties, which can be tailored for biomedical application requirements by adequate selection of the soft/hard segments ratio of the copolymers.en
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Biomedical Materials Research Part A
dc.subjectpoly(urethane-siloxane) filmsen
dc.subjectbiocompatibilityen
dc.subjectcell adhesionen
dc.subjectcompetitive protein adsorptionen
dc.titleStructure and properties of thermoplastic polyurethanes based on poly(dimethylsiloxane): Assessment of biocompatibilityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractОстојиц, Сања; Гођевац, Дејан; Васиљевић-Радовић, Дана; Пергал, Марија; Несторов, Јелена; Товиловиц, Гордана; Дјонлагиц, Јасна;
dc.citation.volume102
dc.citation.issue11
dc.citation.spage3951
dc.citation.epage3964
dc.citation.other102(11): 3951-3964
dc.citation.rankM21
dc.identifier.pmid24376027
dc.identifier.doi10.1002/jbm.a.35071
dc.identifier.rcubConv_3230
dc.identifier.scopus2-s2.0-84908071472
dc.identifier.wos000343010100019
dc.type.versionpublishedVersion


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