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The electrochemical investigation of inclusion complexes of nifedipine and amlodipine with ß-cyclodextrin and (2-hydroxypropyl)-ß-cyclodextrin

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2013
80709543.pdf (490.4Kb)
Authors
Avramov Ivić, Milka
Stoiljković, Zora
Jovanović, Vladislava M.
Mijin, Dušan
Nikolić, V.
Nikolić, L.j.
Petrović, Slobodan D.
Article (Published version)
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Abstract
The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with ß-cyclodextrin (ßCD) and (2-hydroxypropyl)-ß-cyclodextrin (HPßCD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HPßCD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HPßCD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both electrolytes were shifted t...o the positive direction compared to their standards. In addition, the value of anodic currents decreased.

Keywords:
Cyclic voltammetry / cyclodextrin complexes / Electrochemical determination / Gold electrode / Square wave voltammetry
Source:
International Journal of Electrochemical Science, 2013, 8, 7, 9543-9557
Publisher:
  • Esg, Belgrade
Projects:
  • Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)

ISSN: 1452-3981

Scopus: 2-s2.0-84881578068
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1382
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IHTM

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