The electrochemical investigation of inclusion complexes of nifedipine and amlodipine with ß-cyclodextrin and (2-hydroxypropyl)-ß-cyclodextrin
Authors
Avramov Ivić, Milka
Stoiljković, Zora
Jovanović, Vladislava M.

Mijin, Dušan

Nikolić, V.
Nikolić, L.j.
Petrović, Slobodan D.
Article (Published version)

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The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with ß-cyclodextrin (ßCD) and (2-hydroxypropyl)-ß-cyclodextrin (HPßCD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HPßCD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HPßCD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both electrolytes were shifted t...o the positive direction compared to their standards. In addition, the value of anodic currents decreased.
Keywords:
Cyclic voltammetry / cyclodextrin complexes / Electrochemical determination / Gold electrode / Square wave voltammetrySource:
International Journal of Electrochemical Science, 2013, 8, 7, 9543-9557Publisher:
- Esg, Belgrade
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)
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IHTMTY - JOUR AU - Avramov Ivić, Milka AU - Stoiljković, Zora AU - Jovanović, Vladislava M. AU - Mijin, Dušan AU - Nikolić, V. AU - Nikolić, L.j. AU - Petrović, Slobodan D. PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1382 AB - The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with ß-cyclodextrin (ßCD) and (2-hydroxypropyl)-ß-cyclodextrin (HPßCD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HPßCD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HPßCD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both electrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased. PB - Esg, Belgrade T2 - International Journal of Electrochemical Science T1 - The electrochemical investigation of inclusion complexes of nifedipine and amlodipine with ß-cyclodextrin and (2-hydroxypropyl)-ß-cyclodextrin VL - 8 IS - 7 SP - 9543 EP - 9557 UR - https://hdl.handle.net/21.15107/rcub_cer_1382 ER -
@article{ author = "Avramov Ivić, Milka and Stoiljković, Zora and Jovanović, Vladislava M. and Mijin, Dušan and Nikolić, V. and Nikolić, L.j. and Petrović, Slobodan D.", year = "2013", abstract = "The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with ß-cyclodextrin (ßCD) and (2-hydroxypropyl)-ß-cyclodextrin (HPßCD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HPßCD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HPßCD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both electrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased.", publisher = "Esg, Belgrade", journal = "International Journal of Electrochemical Science", title = "The electrochemical investigation of inclusion complexes of nifedipine and amlodipine with ß-cyclodextrin and (2-hydroxypropyl)-ß-cyclodextrin", volume = "8", number = "7", pages = "9543-9557", url = "https://hdl.handle.net/21.15107/rcub_cer_1382" }
Avramov Ivić, M., Stoiljković, Z., Jovanović, V. M., Mijin, D., Nikolić, V., Nikolić, L.j.,& Petrović, S. D.. (2013). The electrochemical investigation of inclusion complexes of nifedipine and amlodipine with ß-cyclodextrin and (2-hydroxypropyl)-ß-cyclodextrin. in International Journal of Electrochemical Science Esg, Belgrade., 8(7), 9543-9557. https://hdl.handle.net/21.15107/rcub_cer_1382
Avramov Ivić M, Stoiljković Z, Jovanović VM, Mijin D, Nikolić V, Nikolić L, Petrović SD. The electrochemical investigation of inclusion complexes of nifedipine and amlodipine with ß-cyclodextrin and (2-hydroxypropyl)-ß-cyclodextrin. in International Journal of Electrochemical Science. 2013;8(7):9543-9557. https://hdl.handle.net/21.15107/rcub_cer_1382 .
Avramov Ivić, Milka, Stoiljković, Zora, Jovanović, Vladislava M., Mijin, Dušan, Nikolić, V., Nikolić, L.j., Petrović, Slobodan D., "The electrochemical investigation of inclusion complexes of nifedipine and amlodipine with ß-cyclodextrin and (2-hydroxypropyl)-ß-cyclodextrin" in International Journal of Electrochemical Science, 8, no. 7 (2013):9543-9557, https://hdl.handle.net/21.15107/rcub_cer_1382 .