Show simple item record

dc.creatorMilenković, Milica R.
dc.creatorBacchi, Alessia
dc.creatorCantoni, Giulia
dc.creatorRadulovic, Sinisa
dc.creatorGligorijević, Nevenka
dc.creatorArandelovic, Sandra
dc.creatorSladić, Dušan
dc.creatorVujčić, Miroslava
dc.creatorMitić, Dragana
dc.creatorAnđelković, Katarina
dc.date.accessioned2019-01-30T17:37:57Z
dc.date.available2019-01-30T17:37:57Z
dc.date.issued2013
dc.identifier.issn0020-1693
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1356
dc.description.abstractA cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA.en
dc.publisherElsevier Science Sa, Lausanne
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.rightsrestrictedAccess
dc.sourceInorganica Chimica Acta
dc.subjectCobalt(III) complexen
dc.subjectX-rayen
dc.subjectAntitumor activityen
dc.subjectAntimicrobial activityen
dc.subjectDNA bindingen
dc.titleSynthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazateen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиленковиц, Милица; Цантони, Гиулиа; Радуловиц, Синиса; Глигоријевиц, Невенка; Aнђелковиц, Катарина; Вујчић, Мирослава; Сладиц, Дусан; Aранделовиц, Сандра; Митиц, Драгана; Баццхи, Aлессиа;
dc.citation.volume395
dc.citation.spage33
dc.citation.epage43
dc.citation.other395: 33-43
dc.citation.rankM22
dc.identifier.doi10.1016/j.ica.2012.09.043
dc.identifier.rcubConv_2952
dc.identifier.scopus2-s2.0-84870889620
dc.identifier.wos000316740200005
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record