Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate
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2013
Authors
Milenković, Milica R.
Bacchi, Alessia

Cantoni, Giulia
Radulovic, Sinisa
Gligorijević, Nevenka

Arandelovic, Sandra
Sladić, Dušan

Vujčić, Miroslava

Mitić, Dragana

Anđelković, Katarina

Article (Published version)

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A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA.
Keywords:
Cobalt(III) complex / X-ray / Antitumor activity / Antimicrobial activity / DNA bindingSource:
Inorganica Chimica Acta, 2013, 395, 33-43Publisher:
- Elsevier Science Sa, Lausanne
Funding / projects:
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
- Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-41026)
DOI: 10.1016/j.ica.2012.09.043
ISSN: 0020-1693
WoS: 000316740200005
Scopus: 2-s2.0-84870889620
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IHTMTY - JOUR AU - Milenković, Milica R. AU - Bacchi, Alessia AU - Cantoni, Giulia AU - Radulovic, Sinisa AU - Gligorijević, Nevenka AU - Arandelovic, Sandra AU - Sladić, Dušan AU - Vujčić, Miroslava AU - Mitić, Dragana AU - Anđelković, Katarina PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1356 AB - A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA. PB - Elsevier Science Sa, Lausanne T2 - Inorganica Chimica Acta T1 - Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate VL - 395 SP - 33 EP - 43 DO - 10.1016/j.ica.2012.09.043 ER -
@article{ author = "Milenković, Milica R. and Bacchi, Alessia and Cantoni, Giulia and Radulovic, Sinisa and Gligorijević, Nevenka and Arandelovic, Sandra and Sladić, Dušan and Vujčić, Miroslava and Mitić, Dragana and Anđelković, Katarina", year = "2013", abstract = "A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA.", publisher = "Elsevier Science Sa, Lausanne", journal = "Inorganica Chimica Acta", title = "Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate", volume = "395", pages = "33-43", doi = "10.1016/j.ica.2012.09.043" }
Milenković, M. R., Bacchi, A., Cantoni, G., Radulovic, S., Gligorijević, N., Arandelovic, S., Sladić, D., Vujčić, M., Mitić, D.,& Anđelković, K.. (2013). Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate. in Inorganica Chimica Acta Elsevier Science Sa, Lausanne., 395, 33-43. https://doi.org/10.1016/j.ica.2012.09.043
Milenković MR, Bacchi A, Cantoni G, Radulovic S, Gligorijević N, Arandelovic S, Sladić D, Vujčić M, Mitić D, Anđelković K. Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate. in Inorganica Chimica Acta. 2013;395:33-43. doi:10.1016/j.ica.2012.09.043 .
Milenković, Milica R., Bacchi, Alessia, Cantoni, Giulia, Radulovic, Sinisa, Gligorijević, Nevenka, Arandelovic, Sandra, Sladić, Dušan, Vujčić, Miroslava, Mitić, Dragana, Anđelković, Katarina, "Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate" in Inorganica Chimica Acta, 395 (2013):33-43, https://doi.org/10.1016/j.ica.2012.09.043 . .