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Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate

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2013
Authors
Milenković, Milica R.
Bacchi, Alessia
Cantoni, Giulia
Radulovic, Sinisa
Gligorijević, Nevenka
Arandelovic, Sandra
Sladić, Dušan
Vujčić, Miroslava
Mitić, Dragana
Anđelković, Katarina
Article (Published version)
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Abstract
A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA.
Keywords:
Cobalt(III) complex / X-ray / Antitumor activity / Antimicrobial activity / DNA binding
Source:
Inorganica Chimica Acta, 2013, 395, 33-43
Publisher:
  • Elsevier Science Sa, Lausanne
Projects:
  • Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
  • Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-41026)

DOI: 10.1016/j.ica.2012.09.043

ISSN: 0020-1693

WoS: 000316740200005

Scopus: 2-s2.0-84870889620
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1356
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IHTM

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