This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.
Keywords:
Antioxidants / CBMN assay / Heterocyclic compounds / Human lymphocytes DNA
Source:
Mini-Reviews in Medicinal Chemistry, 2013, 13, 3, 431-438
TY - JOUR
AU - Gođevac, Dejan
AU - Tešević, Vele
AU - Vajs, Vlatka
AU - Milosavljević, Slobodan
AU - Stanković, Miroslava
PY - 2013
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1353
AB - This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.
PB - Bentham Science Publ Ltd, Sharjah
T2 - Mini-Reviews in Medicinal Chemistry
T1 - Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay
VL - 13
IS - 3
SP - 431
EP - 438
DO - 10.2174/138955713804999856
ER -
@article{
author = "Gođevac, Dejan and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan and Stanković, Miroslava",
year = "2013",
abstract = "This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Mini-Reviews in Medicinal Chemistry",
title = "Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay",
volume = "13",
number = "3",
pages = "431-438",
doi = "10.2174/138955713804999856"
}
Gođevac, D., Tešević, V., Vajs, V., Milosavljević, S.,& Stanković, M.. (2013). Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay. in Mini-Reviews in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 13(3), 431-438.
https://doi.org/10.2174/138955713804999856
Gođevac D, Tešević V, Vajs V, Milosavljević S, Stanković M. Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay. in Mini-Reviews in Medicinal Chemistry. 2013;13(3):431-438.
doi:10.2174/138955713804999856 .
Gođevac, Dejan, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, Stanković, Miroslava, "Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay" in Mini-Reviews in Medicinal Chemistry, 13, no. 3 (2013):431-438,
https://doi.org/10.2174/138955713804999856 . .
