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dc.creatorMarkovic, Violeta
dc.creatorJanicijevic, Ana
dc.creatorStanojković, Tatjana
dc.creatorKolundzija, Branka
dc.creatorSladić, Dušan
dc.creatorVujčić, Miroslava
dc.creatorJanović, Barbara
dc.creatorJoksovic, Ljubinka
dc.creatorDjurdjevic, Predrag T.
dc.creatorTodorović, Nina
dc.creatorTrifunović, Snežana
dc.creatorJoksovic, Milan D.
dc.date.accessioned2019-01-30T17:37:42Z
dc.date.available2019-01-30T17:37:42Z
dc.date.issued2013
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1343
dc.description.abstractA series of novel anthraquinone thiosemicarbazone derivatives in a tautomerizable keto-imine form was synthesized and tested for their in vitro cytotoxic activity against human cancer cells (HeLa, MDA-MB-361, MDA-MB-453, K562, A549) and human normal MRC-5 cells. Several compounds efficiently inhibited cancer cell growth at micromolar concentrations, especially against K562 and HeLa cells. As determined by flow cytometric analysis, anthraquinone thiosemicarbazone caused significant increase in the number of sub-G1 phase of HeLa cells and apoptosis in a concentration-dependent manner. Also, inhibition of caspase-3, -8, and -9 with specific caspase inhibitors reduced the apoptosis mediated by the tested compounds in HeLa cells. All anthraquinone-thiosemicarbazones exhibit calf thymus DNA-binding activity, but no cleavage of plasmid DNA was observed.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Paris
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectAnthraquinoneen
dc.subjectThiosemicarbazoneen
dc.subjectTautomerismen
dc.subjectcytotoxicityen
dc.subjectDNA-binding studiesen
dc.titleSynthesis, cytotoxic activity and DNA-interaction studies of novel anthraquinone-thiosemicarbazones with tautomerizable methylene groupen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈоксовиц, Љубинка; Вујчић, Мирослава; Јаницијевиц, Aна; Сладиц, Дусан; Јановић, Барбара; Марковиц, Виолета; Станојковиц, Татјана; Трифуновиц, Снезана; Колундзија, Бранка; Јоксовиц, Милан Д.; Дјурдјевиц, Предраг Т.; Тодоровић, Нина;
dc.citation.volume64
dc.citation.spage228
dc.citation.epage238
dc.citation.other64: 228-238
dc.citation.rankM21
dc.identifier.pmid23644206
dc.identifier.doi10.1016/j.ejmech.2013.03.071
dc.identifier.rcubConv_2995
dc.identifier.scopus2-s2.0-84877040246
dc.identifier.wos000321230300024
dc.type.versionpublishedVersion


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