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dc.creatorMatić, Ivana Z.
dc.creatorJuranić, Zorica
dc.creatorSavikin, Katarina
dc.creatorZdunić, Gordana
dc.creatorNadvinski, Neva
dc.creatorGođevac, Dejan
dc.date.accessioned2019-01-30T17:37:34Z
dc.date.available2019-01-30T17:37:34Z
dc.date.issued2013
dc.identifier.issn0951-418X
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/1338
dc.description.abstractWith the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose-dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem-x cells in comparison to the action to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46013/RS//
dc.rightsrestrictedAccess
dc.sourcePhytotherapy Research
dc.subjectantioxidant activityen
dc.subjectchamomile teaen
dc.subjectchemical profileen
dc.subjectcytotoxic effecten
dc.subjectmarigold teaen
dc.titleChamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГођевац, Дејан; Здуниц, Гордана; Матиц, Ивана З.; Јураниц, Зорица; Надвински, Нева; Савикин, Катарина;
dc.citation.volume27
dc.citation.issue6
dc.citation.spage852
dc.citation.epage858
dc.citation.other27(6): 852-858
dc.citation.rankM22
dc.identifier.pmid22899374
dc.identifier.doi10.1002/ptr.4807
dc.identifier.scopus2-s2.0-84878827887
dc.identifier.wos000320114500009
dc.type.versionpublishedVersion


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Приказ основних података о документу