Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity
Само за регистроване кориснике
2013
Аутори
Matić, Ivana Z.Juranić, Zorica
Savikin, Katarina
Zdunić, Gordana
Nadvinski, Neva
Gođevac, Dejan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
With the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose-dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem-x cells in comparison to the act...ion to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated.
Кључне речи:
antioxidant activity / chamomile tea / chemical profile / cytotoxic effect / marigold teaИзвор:
Phytotherapy Research, 2013, 27, 6, 852-858Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Модификатори биолошког одговора у физиолошким и патолошким стањима (RS-MESTD-Basic Research (BR or ON)-175011)
- Традиционални и нови производи од плодова гајених и самониклих врста воћака и винове лозе и нус-продуката у преради, са посебним освртом на аутохтоне сорте: хемијска карактеризација и биолошки профил (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46013)
DOI: 10.1002/ptr.4807
ISSN: 0951-418X
PubMed: 22899374
WoS: 000320114500009
Scopus: 2-s2.0-84878827887
Институција/група
IHTMTY - JOUR AU - Matić, Ivana Z. AU - Juranić, Zorica AU - Savikin, Katarina AU - Zdunić, Gordana AU - Nadvinski, Neva AU - Gođevac, Dejan PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1338 AB - With the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose-dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem-x cells in comparison to the action to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated. PB - Wiley, Hoboken T2 - Phytotherapy Research T1 - Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity VL - 27 IS - 6 SP - 852 EP - 858 DO - 10.1002/ptr.4807 ER -
@article{ author = "Matić, Ivana Z. and Juranić, Zorica and Savikin, Katarina and Zdunić, Gordana and Nadvinski, Neva and Gođevac, Dejan", year = "2013", abstract = "With the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose-dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem-x cells in comparison to the action to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated.", publisher = "Wiley, Hoboken", journal = "Phytotherapy Research", title = "Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity", volume = "27", number = "6", pages = "852-858", doi = "10.1002/ptr.4807" }
Matić, I. Z., Juranić, Z., Savikin, K., Zdunić, G., Nadvinski, N.,& Gođevac, D.. (2013). Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity. in Phytotherapy Research Wiley, Hoboken., 27(6), 852-858. https://doi.org/10.1002/ptr.4807
Matić IZ, Juranić Z, Savikin K, Zdunić G, Nadvinski N, Gođevac D. Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity. in Phytotherapy Research. 2013;27(6):852-858. doi:10.1002/ptr.4807 .
Matić, Ivana Z., Juranić, Zorica, Savikin, Katarina, Zdunić, Gordana, Nadvinski, Neva, Gođevac, Dejan, "Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity" in Phytotherapy Research, 27, no. 6 (2013):852-858, https://doi.org/10.1002/ptr.4807 . .