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Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity

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2013
Authors
Matić, Ivana Z.
Juranić, Zorica
Savikin, Katarina
Zdunić, Gordana
Nadvinski, Neva
Gođevac, Dejan
Article (Published version)
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Abstract
With the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose-dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem-x cells in comparison to the act...ion to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated.

Keywords:
antioxidant activity / chamomile tea / chemical profile / cytotoxic effect / marigold tea
Source:
Phytotherapy Research, 2013, 27, 6, 852-858
Publisher:
  • Wiley, Hoboken
Projects:
  • Biological response modifiers in physiological and pathological conditions (RS-175011)
  • Traditional and new products of cultivated and wild growing fruits and grape vines, and by-products durring processing, with special emphasis on indigenous varieties: chemical characterization and biological profile (RS-46013)

DOI: 10.1002/ptr.4807

ISSN: 0951-418X

PubMed: 22899374

WoS: 000320114500009

Scopus: 2-s2.0-84878827887
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1338
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IHTM

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