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dc.creatorMenković, Nebojša
dc.creatorGođevac, Dejan
dc.creatorSavikin, Katarina
dc.creatorZdunić, Gordana
dc.creatorMilosavljević, Slobodan
dc.creatorBojadzi, Andon
dc.creatorAvramoski, Oliver
dc.date.accessioned2019-01-30T17:37:29Z
dc.date.available2019-01-30T17:37:29Z
dc.date.issued2013
dc.identifier.issn1307-6167
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1333
dc.description.abstractCollection of Sideritis raeseri subsp. raeseri has a long tradition in local communities in the Ohrid-Prespa region. The aim of the present study was the analysis of bioactive compounds especially those with anti-inflammatory activity. Combination of the UV and MS data allowed the characterization of 17 compounds, which could be classified into flavonoid glycosides or hydroxycynnamic acid derivatives. Six of them were isolated using preparative HPLC: isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, hypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside, 4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside and 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside. The presence of phenylpropanoid glycoside martynoside was reported for the first time in the wild growing S. raeseri subsp. raeseri. Hypolaetin derivatives, known for their antiinflammatory activity, dominated and were more abundant in S. raeseri subsp. raeseri grown in NPG in comparison with S. scardica grown nearby the NPG. The type of solvent affected distribution and the amount of bioactive compounds and the advantage was given to less polar extracts which were richer in hypolaetin derivatives.en
dc.publisherACG Publications
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46013/RS//
dc.rightsopenAccess
dc.sourceRecords of Natural Products
dc.subjectSideritisen
dc.subjectpolar extractsen
dc.subjectpolyphenolsen
dc.subjectLC/MSen
dc.titleBioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicicaen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractЗдуниц, Гордана; Савикин, Катарина; Милосављевиц, Слободан; Менковиц, Небојса; Гођевац, Дејан; Aврамоски, Оливер; Бојадзи, Aндон;
dc.citation.volume7
dc.citation.issue3
dc.citation.spage161
dc.citation.epage168
dc.citation.other7(3): 161-168
dc.citation.rankM22
dc.identifier.rcubConv_2983
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/14484/26-RNP-1210-170.pdf
dc.identifier.scopus2-s2.0-84878435503
dc.identifier.wos000319558500001
dc.type.versionpublishedVersion


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