Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica
Autori
Menković, NebojšaGođevac, Dejan

Savikin, Katarina
Zdunić, Gordana

Milosavljević, Slobodan

Bojadzi, Andon
Avramoski, Oliver
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Collection of Sideritis raeseri subsp. raeseri has a long tradition in local communities in the Ohrid-Prespa region. The aim of the present study was the analysis of bioactive compounds especially those with anti-inflammatory activity. Combination of the UV and MS data allowed the characterization of 17 compounds, which could be classified into flavonoid glycosides or hydroxycynnamic acid derivatives. Six of them were isolated using preparative HPLC: isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, hypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside, 4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside and 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allo...pyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside. The presence of phenylpropanoid glycoside martynoside was reported for the first time in the wild growing S. raeseri subsp. raeseri. Hypolaetin derivatives, known for their antiinflammatory activity, dominated and were more abundant in S. raeseri subsp. raeseri grown in NPG in comparison with S. scardica grown nearby the NPG. The type of solvent affected distribution and the amount of bioactive compounds and the advantage was given to less polar extracts which were richer in hypolaetin derivatives.
Ključne reči:
Sideritis / polar extracts / polyphenols / LC/MSIzvor:
Records of Natural Products, 2013, 7, 3, 161-168Izdavač:
- ACG Publications
Finansiranje / projekti:
Institucija/grupa
IHTMTY - JOUR AU - Menković, Nebojša AU - Gođevac, Dejan AU - Savikin, Katarina AU - Zdunić, Gordana AU - Milosavljević, Slobodan AU - Bojadzi, Andon AU - Avramoski, Oliver PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1333 AB - Collection of Sideritis raeseri subsp. raeseri has a long tradition in local communities in the Ohrid-Prespa region. The aim of the present study was the analysis of bioactive compounds especially those with anti-inflammatory activity. Combination of the UV and MS data allowed the characterization of 17 compounds, which could be classified into flavonoid glycosides or hydroxycynnamic acid derivatives. Six of them were isolated using preparative HPLC: isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, hypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside, 4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside and 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside. The presence of phenylpropanoid glycoside martynoside was reported for the first time in the wild growing S. raeseri subsp. raeseri. Hypolaetin derivatives, known for their antiinflammatory activity, dominated and were more abundant in S. raeseri subsp. raeseri grown in NPG in comparison with S. scardica grown nearby the NPG. The type of solvent affected distribution and the amount of bioactive compounds and the advantage was given to less polar extracts which were richer in hypolaetin derivatives. PB - ACG Publications T2 - Records of Natural Products T1 - Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica VL - 7 IS - 3 SP - 161 EP - 168 UR - https://hdl.handle.net/21.15107/rcub_cer_1333 ER -
@article{ author = "Menković, Nebojša and Gođevac, Dejan and Savikin, Katarina and Zdunić, Gordana and Milosavljević, Slobodan and Bojadzi, Andon and Avramoski, Oliver", year = "2013", abstract = "Collection of Sideritis raeseri subsp. raeseri has a long tradition in local communities in the Ohrid-Prespa region. The aim of the present study was the analysis of bioactive compounds especially those with anti-inflammatory activity. Combination of the UV and MS data allowed the characterization of 17 compounds, which could be classified into flavonoid glycosides or hydroxycynnamic acid derivatives. Six of them were isolated using preparative HPLC: isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, hypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside, 4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside and 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside. The presence of phenylpropanoid glycoside martynoside was reported for the first time in the wild growing S. raeseri subsp. raeseri. Hypolaetin derivatives, known for their antiinflammatory activity, dominated and were more abundant in S. raeseri subsp. raeseri grown in NPG in comparison with S. scardica grown nearby the NPG. The type of solvent affected distribution and the amount of bioactive compounds and the advantage was given to less polar extracts which were richer in hypolaetin derivatives.", publisher = "ACG Publications", journal = "Records of Natural Products", title = "Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica", volume = "7", number = "3", pages = "161-168", url = "https://hdl.handle.net/21.15107/rcub_cer_1333" }
Menković, N., Gođevac, D., Savikin, K., Zdunić, G., Milosavljević, S., Bojadzi, A.,& Avramoski, O.. (2013). Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica. in Records of Natural Products ACG Publications., 7(3), 161-168. https://hdl.handle.net/21.15107/rcub_cer_1333
Menković N, Gođevac D, Savikin K, Zdunić G, Milosavljević S, Bojadzi A, Avramoski O. Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica. in Records of Natural Products. 2013;7(3):161-168. https://hdl.handle.net/21.15107/rcub_cer_1333 .
Menković, Nebojša, Gođevac, Dejan, Savikin, Katarina, Zdunić, Gordana, Milosavljević, Slobodan, Bojadzi, Andon, Avramoski, Oliver, "Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica" in Records of Natural Products, 7, no. 3 (2013):161-168, https://hdl.handle.net/21.15107/rcub_cer_1333 .