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dc.creatorStefanovic, Jovana
dc.creatorJakovljević, Dragica
dc.creatorGojgić-Cvijović, Gordana
dc.creatorLazić, Miodrag L.
dc.creatorVrvić, Miroslav
dc.date.accessioned2019-01-30T17:36:57Z
dc.date.available2019-01-30T17:36:57Z
dc.date.issued2013
dc.identifier.issn0021-8995
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/1311
dc.description.abstractNystatin, a polyene tetraene antibiotic widely used in the treatment of mycoses, was coupled with oxidized polysaccharide gum Arabic, by forming Schiff base structures between amine groups of antibiotics and aldehyde groups of modified carbohydrate. Imine conjugates synthesized in this way were reduced with sodium borohydride to secondary amines. Two imine and two amine conjugates were obtained with different nystatin content. The conjugates were characterized by UVVis, FTIR, 1H NMR spectroscopy, and thermogravimetric analysis. Solubility in water, unlike nystatin, and significant activity against Candida albicans and Aspergillus niger with minimum inhibitory concentrations in range of 3.1256.25 mu g mL-1 and 6.2525 mu g mL-1, respectively, indicate that the chemical integrity and the biological function of these compounds were retained. A comparison of stability of the conjugates in the dry form, solution and under different pH values showed that the conjugates exhibited better stability than pure drug.en
dc.publisherWiley-Blackwell, Malden
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Applied Polymer Science
dc.subjectnystatinen
dc.subjectpolysaccharideen
dc.subjectcouplingen
dc.subjectsolubilityen
dc.subjectantifungal activityen
dc.titleSynthesis, characterization, and antifungal activity of nystatingum arabic conjugatesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈаковљевић, Драгица; Врвиц, Мирослав; Стефановиц, Јована; Гојгић Цвијовић, Гордана; Лазић, Миодраг Л.;
dc.citation.volume127
dc.citation.issue6
dc.citation.spage4736
dc.citation.epage4743
dc.citation.other127(6): 4736-4743
dc.citation.rankM22
dc.identifier.doi10.1002/app.38084
dc.identifier.rcubConv_2903
dc.identifier.scopus2-s2.0-84871615987
dc.identifier.wos000312940400064
dc.type.versionpublishedVersion


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