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Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates

Authorized Users Only
2013
Authors
Stefanovic, Jovana
Jakovljević, Dragica
Gojgić-Cvijović, Gordana
Lazić, Miodrag L.
Vrvić, Miroslav
Article (Published version)
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Abstract
Nystatin, a polyene tetraene antibiotic widely used in the treatment of mycoses, was coupled with oxidized polysaccharide gum Arabic, by forming Schiff base structures between amine groups of antibiotics and aldehyde groups of modified carbohydrate. Imine conjugates synthesized in this way were reduced with sodium borohydride to secondary amines. Two imine and two amine conjugates were obtained with different nystatin content. The conjugates were characterized by UVVis, FTIR, 1H NMR spectroscopy, and thermogravimetric analysis. Solubility in water, unlike nystatin, and significant activity against Candida albicans and Aspergillus niger with minimum inhibitory concentrations in range of 3.1256.25 mu g mL-1 and 6.2525 mu g mL-1, respectively, indicate that the chemical integrity and the biological function of these compounds were retained. A comparison of stability of the conjugates in the dry form, solution and under different pH values showed that the conjugates exhibited better stabil...ity than pure drug.

Keywords:
nystatin / polysaccharide / coupling / solubility / antifungal activity
Source:
Journal of Applied Polymer Science, 2013, 127, 6, 4736-4743
Publisher:
  • Wiley-Blackwell, Malden
Funding / projects:
  • Simultaneous Bioremediation and Soilification of Degraded Areas to Preserve Natural Resources of Biologically Active Substances, and Development and Production of Biomaterials and Dietetic Products (RS-43004)

DOI: 10.1002/app.38084

ISSN: 0021-8995

WoS: 000312940400064

Scopus: 2-s2.0-84871615987
[ Google Scholar ]
16
15
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/1311
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Stefanovic, Jovana
AU  - Jakovljević, Dragica
AU  - Gojgić-Cvijović, Gordana
AU  - Lazić, Miodrag L.
AU  - Vrvić, Miroslav
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1311
AB  - Nystatin, a polyene tetraene antibiotic widely used in the treatment of mycoses, was coupled with oxidized polysaccharide gum Arabic, by forming Schiff base structures between amine groups of antibiotics and aldehyde groups of modified carbohydrate. Imine conjugates synthesized in this way were reduced with sodium borohydride to secondary amines. Two imine and two amine conjugates were obtained with different nystatin content. The conjugates were characterized by UVVis, FTIR, 1H NMR spectroscopy, and thermogravimetric analysis. Solubility in water, unlike nystatin, and significant activity against Candida albicans and Aspergillus niger with minimum inhibitory concentrations in range of 3.1256.25 mu g mL-1 and 6.2525 mu g mL-1, respectively, indicate that the chemical integrity and the biological function of these compounds were retained. A comparison of stability of the conjugates in the dry form, solution and under different pH values showed that the conjugates exhibited better stability than pure drug.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Applied Polymer Science
T1  - Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates
VL  - 127
IS  - 6
SP  - 4736
EP  - 4743
DO  - 10.1002/app.38084
ER  - 
@article{
author = "Stefanovic, Jovana and Jakovljević, Dragica and Gojgić-Cvijović, Gordana and Lazić, Miodrag L. and Vrvić, Miroslav",
year = "2013",
abstract = "Nystatin, a polyene tetraene antibiotic widely used in the treatment of mycoses, was coupled with oxidized polysaccharide gum Arabic, by forming Schiff base structures between amine groups of antibiotics and aldehyde groups of modified carbohydrate. Imine conjugates synthesized in this way were reduced with sodium borohydride to secondary amines. Two imine and two amine conjugates were obtained with different nystatin content. The conjugates were characterized by UVVis, FTIR, 1H NMR spectroscopy, and thermogravimetric analysis. Solubility in water, unlike nystatin, and significant activity against Candida albicans and Aspergillus niger with minimum inhibitory concentrations in range of 3.1256.25 mu g mL-1 and 6.2525 mu g mL-1, respectively, indicate that the chemical integrity and the biological function of these compounds were retained. A comparison of stability of the conjugates in the dry form, solution and under different pH values showed that the conjugates exhibited better stability than pure drug.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Applied Polymer Science",
title = "Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates",
volume = "127",
number = "6",
pages = "4736-4743",
doi = "10.1002/app.38084"
}
Stefanovic, J., Jakovljević, D., Gojgić-Cvijović, G., Lazić, M. L.,& Vrvić, M.. (2013). Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates. in Journal of Applied Polymer Science
Wiley-Blackwell, Malden., 127(6), 4736-4743.
https://doi.org/10.1002/app.38084
Stefanovic J, Jakovljević D, Gojgić-Cvijović G, Lazić ML, Vrvić M. Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates. in Journal of Applied Polymer Science. 2013;127(6):4736-4743.
doi:10.1002/app.38084 .
Stefanovic, Jovana, Jakovljević, Dragica, Gojgić-Cvijović, Gordana, Lazić, Miodrag L., Vrvić, Miroslav, "Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates" in Journal of Applied Polymer Science, 127, no. 6 (2013):4736-4743,
https://doi.org/10.1002/app.38084 . .

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