Show simple item record

dc.creatorJadranin, Milka
dc.creatorPešić, Milica
dc.creatorAljančić, Ivana
dc.creatorMilosavljević, Slobodan
dc.creatorTodorović, Nina
dc.creatorPodolski-Renic, Ana
dc.creatorBankovic, Jasna
dc.creatorTanic, Nikola
dc.creatorMarkovic, Ivanka
dc.creatorVajs, Vlatka
dc.creatorTešević, Vele
dc.date.accessioned2019-01-30T17:36:16Z
dc.date.available2019-01-30T17:36:16Z
dc.date.issued2013
dc.identifier.issn0031-9422
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1278
dc.description.abstractThirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS//
dc.rightsrestrictedAccess
dc.sourcePhytochemistry
dc.subjectEuphorbia dendroidesen
dc.subjectEuphorbiaceaeen
dc.subjectIsolationen
dc.subjectJatrophanesen
dc.subjectEuphodendrophanes G-Sen
dc.subjectP-glycoproteinen
dc.subjectMulti-drug resistanceen
dc.titleJatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell linesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТесевиц, Веле В.; Вајс, Влатка Е.; Таниц, Никола; Банковиц, Јасна; Јадранин, Милка; Подолски-Рениц, Aна; Aљанчић, Ивана С.; Тодоровић, Нина; Милосављевиц, Слободан М.; Марковиц, Иванка; Песиц, Милица;
dc.citation.volume86
dc.citation.spage208
dc.citation.epage217
dc.citation.other86: 208-217
dc.citation.rankM21
dc.identifier.pmid23079764
dc.identifier.doi10.1016/j.phytochem.2012.09.003
dc.identifier.rcubConv_2926
dc.identifier.scopus2-s2.0-84872042428
dc.identifier.wos000315017100024
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record