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An electrochemical illustration of the mathematical modelling of chlorine impact and acidification in electrochemical tumour treatment and its application on an agar-agar gel system

Authorized Users Only
2003
Authors
Avramov Ivić, Milka
Perovic, SD
Živković, Predrag M.
Nikolić, Nebojša D.
Popov, Konstantin I.
Article (Published version)
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Abstract
Electrochemical treatment (EchT) of tumours, which is also known as electrochemical therapy, implies that tumour tissue is treated with a direct current through the use of electrodes. This was shown earlier when the major electrochemical reactions at the anode were chlorine and oxygen evolution and the impact of chlorine in EchT was investigated by mathematical modelling. In this work the electrochemical illustration of a mathematical model of electrochemical treatment of tumours is presented using a Pt electrode placed in agar-agar gel containing 1% phenolphthalein and NaCl. The appearance of the bright red color around the Pt wire due to the pH change caused by hydrogen evolution is used for the simulation of the shape and the boundaries of the tumour tissue. After the polarity was changed, oxygen evolution takes place on the Pt wire electrode and the red color disappears simulating the destructive influence of the electrochemical process on tumour tissue. A better understanding of t...he mathematical model presented earlier is achieved and it can be used for educational purposes in oncological praxis because agar-agar is the closest approximation to the ground substance of connective human tissue and successfully simulates the processes which occur in vivo. There is also some quantitative agreement between the results calculated earlier and those obtained in this work. The previous model was based on tissue, which was treated as an aqueous solution of sodium chloride containing bicarbonate and proteins and the results presented a detailed and useful quantitative analysis of the system. In this work, the quantitative analysis presented is based on an agar-agar system and the experimental conditions give the possibility of more detailed qualitative analysis. The combination of these two models offers a better simulation of the processes in vivo.

Keywords:
electrochemical simulation of tumour formation and destruction / agar-agar gel / platinum electrode / hydrogen evolution / oxygen evolution
Source:
Journal of Electroanalytical Chemistry, 2003, 549, 129-135
Publisher:
  • Elsevier

DOI: 10.1016/S0022-0728(03)00251-1

ISSN: 1572-6657

WoS: 000183792100013

Scopus: 2-s2.0-0038070082
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8
8
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/126
Collections
  • Radovi istraživača / Researchers' publications
Institution
IHTM
TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Perovic, SD
AU  - Živković, Predrag M.
AU  - Nikolić, Nebojša D.
AU  - Popov, Konstantin I.
PY  - 2003
UR  - http://cer.ihtm.bg.ac.rs/handle/123456789/126
AB  - Electrochemical treatment (EchT) of tumours, which is also known as electrochemical therapy, implies that tumour tissue is treated with a direct current through the use of electrodes. This was shown earlier when the major electrochemical reactions at the anode were chlorine and oxygen evolution and the impact of chlorine in EchT was investigated by mathematical modelling. In this work the electrochemical illustration of a mathematical model of electrochemical treatment of tumours is presented using a Pt electrode placed in agar-agar gel containing 1% phenolphthalein and NaCl. The appearance of the bright red color around the Pt wire due to the pH change caused by hydrogen evolution is used for the simulation of the shape and the boundaries of the tumour tissue. After the polarity was changed, oxygen evolution takes place on the Pt wire electrode and the red color disappears simulating the destructive influence of the electrochemical process on tumour tissue. A better understanding of the mathematical model presented earlier is achieved and it can be used for educational purposes in oncological praxis because agar-agar is the closest approximation to the ground substance of connective human tissue and successfully simulates the processes which occur in vivo. There is also some quantitative agreement between the results calculated earlier and those obtained in this work. The previous model was based on tissue, which was treated as an aqueous solution of sodium chloride containing bicarbonate and proteins and the results presented a detailed and useful quantitative analysis of the system. In this work, the quantitative analysis presented is based on an agar-agar system and the experimental conditions give the possibility of more detailed qualitative analysis. The combination of these two models offers a better simulation of the processes in vivo.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - An electrochemical illustration of the mathematical modelling of chlorine impact and acidification in electrochemical tumour treatment and its application on an agar-agar gel system
VL  - 549
SP  - 129
EP  - 135
DO  - 10.1016/S0022-0728(03)00251-1
ER  - 
@article{
author = "Avramov Ivić, Milka and Perovic, SD and Živković, Predrag M. and Nikolić, Nebojša D. and Popov, Konstantin I.",
year = "2003",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/126",
abstract = "Electrochemical treatment (EchT) of tumours, which is also known as electrochemical therapy, implies that tumour tissue is treated with a direct current through the use of electrodes. This was shown earlier when the major electrochemical reactions at the anode were chlorine and oxygen evolution and the impact of chlorine in EchT was investigated by mathematical modelling. In this work the electrochemical illustration of a mathematical model of electrochemical treatment of tumours is presented using a Pt electrode placed in agar-agar gel containing 1% phenolphthalein and NaCl. The appearance of the bright red color around the Pt wire due to the pH change caused by hydrogen evolution is used for the simulation of the shape and the boundaries of the tumour tissue. After the polarity was changed, oxygen evolution takes place on the Pt wire electrode and the red color disappears simulating the destructive influence of the electrochemical process on tumour tissue. A better understanding of the mathematical model presented earlier is achieved and it can be used for educational purposes in oncological praxis because agar-agar is the closest approximation to the ground substance of connective human tissue and successfully simulates the processes which occur in vivo. There is also some quantitative agreement between the results calculated earlier and those obtained in this work. The previous model was based on tissue, which was treated as an aqueous solution of sodium chloride containing bicarbonate and proteins and the results presented a detailed and useful quantitative analysis of the system. In this work, the quantitative analysis presented is based on an agar-agar system and the experimental conditions give the possibility of more detailed qualitative analysis. The combination of these two models offers a better simulation of the processes in vivo.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "An electrochemical illustration of the mathematical modelling of chlorine impact and acidification in electrochemical tumour treatment and its application on an agar-agar gel system",
volume = "549",
pages = "129-135",
doi = "10.1016/S0022-0728(03)00251-1"
}
Avramov Ivić M, Perovic S, Živković PM, Nikolić ND, Popov KI. An electrochemical illustration of the mathematical modelling of chlorine impact and acidification in electrochemical tumour treatment and its application on an agar-agar gel system. Journal of Electroanalytical Chemistry. 2003;549:129-135
Avramov Ivić, M., Perovic, S., Živković, P. M., Nikolić, N. D.,& Popov, K. I. (2003). An electrochemical illustration of the mathematical modelling of chlorine impact and acidification in electrochemical tumour treatment and its application on an agar-agar gel system.
Journal of Electroanalytical ChemistryElsevier., 549, 129-135.
https://doi.org/10.1016/S0022-0728(03)00251-1
Avramov Ivić Milka, Perovic SD, Živković Predrag M., Nikolić Nebojša D., Popov Konstantin I., "An electrochemical illustration of the mathematical modelling of chlorine impact and acidification in electrochemical tumour treatment and its application on an agar-agar gel system" 549 (2003):129-135,
https://doi.org/10.1016/S0022-0728(03)00251-1 .

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