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Synthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino) benzylidene]hydrazinecarboxylate and monodentate pseudohalides
dc.creator | Milenković, Milica R. | |
dc.creator | Bacchi, Alessia | |
dc.creator | Cantoni, Giulia | |
dc.creator | Vilipić, Jovana | |
dc.creator | Sladić, Dušan | |
dc.creator | Vujčić, Miroslava | |
dc.creator | Gligorijević, Nevenka | |
dc.creator | Jovanovic, Katarina | |
dc.creator | Radulovic, Sinisa | |
dc.creator | Anđelković, Katarina | |
dc.date.accessioned | 2019-01-30T17:36:01Z | |
dc.date.available | 2019-01-30T17:36:01Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1266 | |
dc.description.abstract | Three square-planar complexes of nickel(II) with the tridentate condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate, and monodentate pseudohalides, have been synthesized. Their crystal structures have been determined. All the complexes showed a significant antifungal activity, while only the azido complex displayed antibacterial activity. All the complexes were cytotoxic to a panel of six tumor cell lines, the azido complex showing a similar activity as cisplatin to leukemia cell line K562 and lower toxicity to normal MRC-5 cells than that anticancer agent. The complexes interfered with cell cycle of tumor cells and induced plasmid DNA cleavage. | en |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Paris | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Medicinal Chemistry | |
dc.subject | Nickel(II) complexes | en |
dc.subject | Pseudohalides | en |
dc.subject | X-ray crystal structures | en |
dc.subject | Antimicrobial activity | en |
dc.subject | cytotoxicity | en |
dc.title | Synthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino) benzylidene]hydrazinecarboxylate and monodentate pseudohalides | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Глигоријевиц, Невенка; Радуловиц, Синиса; Баццхи, Aлессиа; Миленковиц, Милица; Вујчић, Мирослава; Сладиц, Дусан; Вилипиц, Јована; Aнђелковиц, Катарина; Јовановиц, Катарина; Цантони, Гиулиа; | |
dc.citation.volume | 68 | |
dc.citation.spage | 111 | |
dc.citation.epage | 120 | |
dc.citation.other | 68: 111-120 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 23973823 | |
dc.identifier.doi | 10.1016/j.ejmech.2013.07.039 | |
dc.identifier.scopus | 2-s2.0-84882423179 | |
dc.identifier.wos | 000326902300013 | |
dc.type.version | publishedVersion |