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dc.creatorMilenković, Milica
dc.creatorBacchi, Alessia
dc.creatorCantoni, Giulia
dc.creatorVilipić, Jovana
dc.creatorSladić, Dušan
dc.creatorVujčić, Miroslava
dc.creatorGligorijević, Nevenka
dc.creatorJovanovic, Katarina
dc.creatorRadulovic, Sinisa
dc.creatorAnđelković, Katarina
dc.date.accessioned2019-01-30T17:36:01Z
dc.date.available2019-01-30T17:36:01Z
dc.date.issued2013
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1266
dc.description.abstractThree square-planar complexes of nickel(II) with the tridentate condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate, and monodentate pseudohalides, have been synthesized. Their crystal structures have been determined. All the complexes showed a significant antifungal activity, while only the azido complex displayed antibacterial activity. All the complexes were cytotoxic to a panel of six tumor cell lines, the azido complex showing a similar activity as cisplatin to leukemia cell line K562 and lower toxicity to normal MRC-5 cells than that anticancer agent. The complexes interfered with cell cycle of tumor cells and induced plasmid DNA cleavage.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Paris
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectNickel(II) complexesen
dc.subjectPseudohalidesen
dc.subjectX-ray crystal structuresen
dc.subjectAntimicrobial activityen
dc.subjectcytotoxicityen
dc.titleSynthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino) benzylidene]hydrazinecarboxylate and monodentate pseudohalidesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГлигоријевиц, Невенка; Радуловиц, Синиса; Баццхи, Aлессиа; Миленковиц, Милица; Вујчић, Мирослава; Сладиц, Дусан; Вилипиц, Јована; Aнђелковиц, Катарина; Јовановиц, Катарина; Цантони, Гиулиа;
dc.citation.volume68
dc.citation.spage111
dc.citation.epage120
dc.citation.other68: 111-120
dc.citation.rankM21
dc.identifier.pmid23973823
dc.identifier.doi10.1016/j.ejmech.2013.07.039
dc.identifier.rcubConv_3070
dc.identifier.scopus2-s2.0-84882423179
dc.identifier.wos000326902300013
dc.type.versionpublishedVersion


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