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Synthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino) benzylidene]hydrazinecarboxylate and monodentate pseudohalides

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2013
Authors
Milenković, Milica R.
Bacchi, Alessia
Cantoni, Giulia
Vilipić, Jovana
Sladić, Dušan
Vujčić, Miroslava
Gligorijević, Nevenka
Jovanovic, Katarina
Radulovic, Sinisa
Anđelković, Katarina
Article (Published version)
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Abstract
Three square-planar complexes of nickel(II) with the tridentate condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate, and monodentate pseudohalides, have been synthesized. Their crystal structures have been determined. All the complexes showed a significant antifungal activity, while only the azido complex displayed antibacterial activity. All the complexes were cytotoxic to a panel of six tumor cell lines, the azido complex showing a similar activity as cisplatin to leukemia cell line K562 and lower toxicity to normal MRC-5 cells than that anticancer agent. The complexes interfered with cell cycle of tumor cells and induced plasmid DNA cleavage.
Keywords:
Nickel(II) complexes / Pseudohalides / X-ray crystal structures / Antimicrobial activity / cytotoxicity
Source:
European Journal of Medicinal Chemistry, 2013, 68, 111-120
Publisher:
  • Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
Projects:
  • Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
  • Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-41026)

DOI: 10.1016/j.ejmech.2013.07.039

ISSN: 0223-5234

PubMed: 23973823

WoS: 000326902300013

Scopus: 2-s2.0-84882423179
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1266
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