The composition and antimicrobial activity of the essential oil of Heracleum sibiricum L. (Apiaceae) was studied. The aerial part of plant was hydro-distilled and chemical composition of the essential oil was analyzed by GC and GC-MS. Forty-six compounds, corresponding to 95.12% of the total oil, were identified. Esters represented the major chemical class (69.55%) while the main constituents were octyl butanoate (36.82%), hexyl butanoate (16.08%), 1-octanol (13.62%) and octyl hexanoate (8.10%). Antibacterial activity of the essential oil and reference antibiotics against nine bacterial strains was tested by the broth microdilution method. The results of the bioassays showed that essential oil had slight antimicrobial activities against all tested microorganisms (MIC and MBC values were in the range of 2431.2 to 9724.8 mu g/mL). Reference antibiotics were active in concentrations between 0.5 and 16.0 mu g/mL. The results confirm that Gram-positive bacteria were more susceptible to the ...essential oil of H. sibiricum, in comparison with Gram-negative bacteria.
TY - JOUR
AU - Miladinovic, Dragoljub L.
AU - Ilic, Budimir S.
AU - Mihajilov-Krstev, Tatjana M.
AU - Nikolic, Dejan M.
AU - Cvetković, Olga
AU - Marković, Marija S.
AU - Miladinovic, Ljiljana C.
PY - 2013
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/1265
AB - The composition and antimicrobial activity of the essential oil of Heracleum sibiricum L. (Apiaceae) was studied. The aerial part of plant was hydro-distilled and chemical composition of the essential oil was analyzed by GC and GC-MS. Forty-six compounds, corresponding to 95.12% of the total oil, were identified. Esters represented the major chemical class (69.55%) while the main constituents were octyl butanoate (36.82%), hexyl butanoate (16.08%), 1-octanol (13.62%) and octyl hexanoate (8.10%). Antibacterial activity of the essential oil and reference antibiotics against nine bacterial strains was tested by the broth microdilution method. The results of the bioassays showed that essential oil had slight antimicrobial activities against all tested microorganisms (MIC and MBC values were in the range of 2431.2 to 9724.8 mu g/mL). Reference antibiotics were active in concentrations between 0.5 and 16.0 mu g/mL. The results confirm that Gram-positive bacteria were more susceptible to the essential oil of H. sibiricum, in comparison with Gram-negative bacteria.
PB - Natural Product Incorporation
T2 - Natural Product Communications
T1 - Antibacterial Activity of the Essential Oil of Heracleum sibiricum
VL - 8
IS - 9
SP - 1309
EP - 1311
ER -
@article{
author = "Miladinovic, Dragoljub L. and Ilic, Budimir S. and Mihajilov-Krstev, Tatjana M. and Nikolic, Dejan M. and Cvetković, Olga and Marković, Marija S. and Miladinovic, Ljiljana C.",
year = "2013",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/1265",
abstract = "The composition and antimicrobial activity of the essential oil of Heracleum sibiricum L. (Apiaceae) was studied. The aerial part of plant was hydro-distilled and chemical composition of the essential oil was analyzed by GC and GC-MS. Forty-six compounds, corresponding to 95.12% of the total oil, were identified. Esters represented the major chemical class (69.55%) while the main constituents were octyl butanoate (36.82%), hexyl butanoate (16.08%), 1-octanol (13.62%) and octyl hexanoate (8.10%). Antibacterial activity of the essential oil and reference antibiotics against nine bacterial strains was tested by the broth microdilution method. The results of the bioassays showed that essential oil had slight antimicrobial activities against all tested microorganisms (MIC and MBC values were in the range of 2431.2 to 9724.8 mu g/mL). Reference antibiotics were active in concentrations between 0.5 and 16.0 mu g/mL. The results confirm that Gram-positive bacteria were more susceptible to the essential oil of H. sibiricum, in comparison with Gram-negative bacteria.",
publisher = "Natural Product Incorporation",
journal = "Natural Product Communications",
title = "Antibacterial Activity of the Essential Oil of Heracleum sibiricum",
volume = "8",
number = "9",
pages = "1309-1311"
}
Miladinovic, D. L., Ilic, B. S., Mihajilov-Krstev, T. M., Nikolic, D. M., Cvetković, O., Marković, M. S.,& Miladinovic, L. C. (2013). Antibacterial Activity of the Essential Oil of Heracleum sibiricum.
Natural Product Communications
Natural Product Incorporation., 8(9), 1309-1311.
Miladinovic DL, Ilic BS, Mihajilov-Krstev TM, Nikolic DM, Cvetković O, Marković MS, Miladinovic LC. Antibacterial Activity of the Essential Oil of Heracleum sibiricum. Natural Product Communications. 2013;8(9):1309-1311
Miladinovic Dragoljub L., Ilic Budimir S., Mihajilov-Krstev Tatjana M., Nikolic Dejan M., Cvetković Olga, Marković Marija S., Miladinovic Ljiljana C., "Antibacterial Activity of the Essential Oil of Heracleum sibiricum" Natural Product Communications, 8, no. 9 (2013):1309-1311
