Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes
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2013
Authors
Antonijevic-Nikolic, MirjanaAntić Stanković, Jelena
Tanasković, Slađana B.
Korabik, Maria J.
Gojgić-Cvijović, Gordana
Vuckovic, Gordana
Article (Published version)
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Show full item recordAbstract
New cationic Cu(II) complexes with N, N', N '', N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: pentanedioic (glutaric acid = glutH(2)), hexanedioic acid (adipic acid = adipH(2)) and decanedioic acid (sebacic acid = sebH(2)) of general formula [Cu-4(L)(tpmc)(2)] (ClO4)(6)center dot xH(2)O, L = glut, x = 2; L = adip, x = 7; L = seb, x = 6 were isolated. Their composition and charges are proposed based on elemental analyses and molar conductivity measurements. By the comparison of their UV-Vis, reflectance, FTIR and EPR spectral data, CV and SQUID magnetic measurements, with those for the complex with butanedioic acid (succinic acid = succH(2)) of known molecular structure and analysis of LC/MS spectra, geometry with two [Cu(2)tpmc](4) units bridged by dicarboxylate dianion engaging all oxygens is proposed. Within units, Cu(II) ions are also bridged with -N- portion of cyclam ring. All four complexes were screened to in vitro anti...microbial and cytotoxic activity along with free primary and secondary ligands, Cu(II) salt and solvent controls. Detected antibacterial and cytotoxic activity for the complexes was enhanced in most cases than the corresponding controls.
Keywords:
Copper(II) complexes / Octaazamacrocycle / Aliphatic dicarboxylates / antibacterial and cytotoxic activity / Magnetic propertiesSource:
Journal of Molecular Structure, 2013, 1054, 297-306Publisher:
- Elsevier
Funding / projects:
- Design, synthesis, characterization and assessment of practical applications of coordination and organometallic compounds (RS-172014)
- Biological response modifiers in physiological and pathological conditions (RS-175011)
- Polish National Science Centre - NN204 198240
DOI: 10.1016/j.molstruc.2013.10.006
ISSN: 0022-2860
WoS: 000327921100039
Scopus: 2-s2.0-84886104454
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IHTMTY - JOUR AU - Antonijevic-Nikolic, Mirjana AU - Antić Stanković, Jelena AU - Tanasković, Slađana B. AU - Korabik, Maria J. AU - Gojgić-Cvijović, Gordana AU - Vuckovic, Gordana PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1259 AB - New cationic Cu(II) complexes with N, N', N '', N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: pentanedioic (glutaric acid = glutH(2)), hexanedioic acid (adipic acid = adipH(2)) and decanedioic acid (sebacic acid = sebH(2)) of general formula [Cu-4(L)(tpmc)(2)] (ClO4)(6)center dot xH(2)O, L = glut, x = 2; L = adip, x = 7; L = seb, x = 6 were isolated. Their composition and charges are proposed based on elemental analyses and molar conductivity measurements. By the comparison of their UV-Vis, reflectance, FTIR and EPR spectral data, CV and SQUID magnetic measurements, with those for the complex with butanedioic acid (succinic acid = succH(2)) of known molecular structure and analysis of LC/MS spectra, geometry with two [Cu(2)tpmc](4) units bridged by dicarboxylate dianion engaging all oxygens is proposed. Within units, Cu(II) ions are also bridged with -N- portion of cyclam ring. All four complexes were screened to in vitro antimicrobial and cytotoxic activity along with free primary and secondary ligands, Cu(II) salt and solvent controls. Detected antibacterial and cytotoxic activity for the complexes was enhanced in most cases than the corresponding controls. PB - Elsevier T2 - Journal of Molecular Structure T1 - Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes VL - 1054 SP - 297 EP - 306 DO - 10.1016/j.molstruc.2013.10.006 ER -
@article{ author = "Antonijevic-Nikolic, Mirjana and Antić Stanković, Jelena and Tanasković, Slađana B. and Korabik, Maria J. and Gojgić-Cvijović, Gordana and Vuckovic, Gordana", year = "2013", abstract = "New cationic Cu(II) complexes with N, N', N '', N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: pentanedioic (glutaric acid = glutH(2)), hexanedioic acid (adipic acid = adipH(2)) and decanedioic acid (sebacic acid = sebH(2)) of general formula [Cu-4(L)(tpmc)(2)] (ClO4)(6)center dot xH(2)O, L = glut, x = 2; L = adip, x = 7; L = seb, x = 6 were isolated. Their composition and charges are proposed based on elemental analyses and molar conductivity measurements. By the comparison of their UV-Vis, reflectance, FTIR and EPR spectral data, CV and SQUID magnetic measurements, with those for the complex with butanedioic acid (succinic acid = succH(2)) of known molecular structure and analysis of LC/MS spectra, geometry with two [Cu(2)tpmc](4) units bridged by dicarboxylate dianion engaging all oxygens is proposed. Within units, Cu(II) ions are also bridged with -N- portion of cyclam ring. All four complexes were screened to in vitro antimicrobial and cytotoxic activity along with free primary and secondary ligands, Cu(II) salt and solvent controls. Detected antibacterial and cytotoxic activity for the complexes was enhanced in most cases than the corresponding controls.", publisher = "Elsevier", journal = "Journal of Molecular Structure", title = "Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes", volume = "1054", pages = "297-306", doi = "10.1016/j.molstruc.2013.10.006" }
Antonijevic-Nikolic, M., Antić Stanković, J., Tanasković, S. B., Korabik, M. J., Gojgić-Cvijović, G.,& Vuckovic, G.. (2013). Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes. in Journal of Molecular Structure Elsevier., 1054, 297-306. https://doi.org/10.1016/j.molstruc.2013.10.006
Antonijevic-Nikolic M, Antić Stanković J, Tanasković SB, Korabik MJ, Gojgić-Cvijović G, Vuckovic G. Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes. in Journal of Molecular Structure. 2013;1054:297-306. doi:10.1016/j.molstruc.2013.10.006 .
Antonijevic-Nikolic, Mirjana, Antić Stanković, Jelena, Tanasković, Slađana B., Korabik, Maria J., Gojgić-Cvijović, Gordana, Vuckovic, Gordana, "Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes" in Journal of Molecular Structure, 1054 (2013):297-306, https://doi.org/10.1016/j.molstruc.2013.10.006 . .