The catalytic abilities of a gold electrode were tested for the quantitative determination of amphetamine (A) and 3,4-methylenedioxy-N-methylamphetamine (MDMA) standards by their oxidation using cyclic voltammetry (CV). The values of the oxidative currents of A and MDMA standards at 0.80 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s-1 were linear functions of the concentration in range of 110.9-258.9 μM and 38.7-229.2 μM, respectively. Square wave voltammetry (SWV) revealed a linear increase of current with the concentration of MDMA (range 30.9-91.6 μM), which enabled the quantitative determination of amphetamine derivates. SWV analysis was also successfully performed in spiked urine samples. A and MDMA in the presence of sucrose and as a content in illegally produced tablets were also determined. The voltammetric determinations of A and MDMA derivatives using CV and SWV at gold a electrode are rapid, selective and simple procedures and their accuracy was confirmed with a refere...nce method, high performance liquid chromatography (HPLC). The analysis of spiked urine samples offers an additional possibility for the rapid detection of A and MDMA in human urine.
Katalitička svojstva elektrode od zlata su testirana za kvantitativno određivanje amfetamina (A) i 3,4-metilendioksi-N-metilamfetamina (MDMA) standarda. Elektroksidacija A i MDMA je praćena cikličnom voltametrijom (CV). Vrednost oksidativnog pika A i MDMA standarda je linearna funkcija koncentracija u opsegu 110,9-258,9 μM (A) i 38,7-229,2 μM (MDMA). Voltametrija sa pravougaonim impulsima (SWV) je pokazala linearnu zavisnost struja od koncentracija za MDMA standard (u opsegu: 30,9-91,6 μM) kao i u spajkovanim uzorcima humanog urina. Uspešno je analiziran i sadržaj A i MDMA u ilegalno proizvedenim tabletama. Voltametrijsko određivanje A i MDMA derivata uz pomoć CV i SWV na elektrodi od zlata je brza, selektivna i jednostavna procedura. Analiza spajkovanih uzoraka urina nudi dodatnu mogućnost za brzu detekciju A i MDMA u humanom urinu.
TY - JOUR
AU - Nevescanin, Marina M.
AU - Avramov Ivić, Milka
AU - Petrović, Slobodan D.
AU - Mijin, Dušan
AU - Stevic, Sonja N. Banovic
AU - Jovanović, Vladislava M.
PY - 2013
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1252
AB - The catalytic abilities of a gold electrode were tested for the quantitative determination of amphetamine (A) and 3,4-methylenedioxy-N-methylamphetamine (MDMA) standards by their oxidation using cyclic voltammetry (CV). The values of the oxidative currents of A and MDMA standards at 0.80 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s-1 were linear functions of the concentration in range of 110.9-258.9 μM and 38.7-229.2 μM, respectively. Square wave voltammetry (SWV) revealed a linear increase of current with the concentration of MDMA (range 30.9-91.6 μM), which enabled the quantitative determination of amphetamine derivates. SWV analysis was also successfully performed in spiked urine samples. A and MDMA in the presence of sucrose and as a content in illegally produced tablets were also determined. The voltammetric determinations of A and MDMA derivatives using CV and SWV at gold a electrode are rapid, selective and simple procedures and their accuracy was confirmed with a reference method, high performance liquid chromatography (HPLC). The analysis of spiked urine samples offers an additional possibility for the rapid detection of A and MDMA in human urine.
AB - Katalitička svojstva elektrode od zlata su testirana za kvantitativno određivanje amfetamina (A) i 3,4-metilendioksi-N-metilamfetamina (MDMA) standarda. Elektroksidacija A i MDMA je praćena cikličnom voltametrijom (CV). Vrednost oksidativnog pika A i MDMA standarda je linearna funkcija koncentracija u opsegu 110,9-258,9 μM (A) i 38,7-229,2 μM (MDMA). Voltametrija sa pravougaonim impulsima (SWV) je pokazala linearnu zavisnost struja od koncentracija za MDMA standard (u opsegu: 30,9-91,6 μM) kao i u spajkovanim uzorcima humanog urina. Uspešno je analiziran i sadržaj A i MDMA u ilegalno proizvedenim tabletama. Voltametrijsko određivanje A i MDMA derivata uz pomoć CV i SWV na elektrodi od zlata je brza, selektivna i jednostavna procedura. Analiza spajkovanih uzoraka urina nudi dodatnu mogućnost za brzu detekciju A i MDMA u humanom urinu.
PB - Serbian Chemical Society
T2 - Journal of the Serbian Chemical Society
T1 - The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine
T1 - Određivanje derivata amfetamina i primena u analizi humanog urina na elektrodi od zlata
VL - 78
IS - 9
SP - 1373
EP - 1385
DO - 10.2298/JSC121228032N
ER -
@article{
author = "Nevescanin, Marina M. and Avramov Ivić, Milka and Petrović, Slobodan D. and Mijin, Dušan and Stevic, Sonja N. Banovic and Jovanović, Vladislava M.",
year = "2013",
abstract = "The catalytic abilities of a gold electrode were tested for the quantitative determination of amphetamine (A) and 3,4-methylenedioxy-N-methylamphetamine (MDMA) standards by their oxidation using cyclic voltammetry (CV). The values of the oxidative currents of A and MDMA standards at 0.80 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s-1 were linear functions of the concentration in range of 110.9-258.9 μM and 38.7-229.2 μM, respectively. Square wave voltammetry (SWV) revealed a linear increase of current with the concentration of MDMA (range 30.9-91.6 μM), which enabled the quantitative determination of amphetamine derivates. SWV analysis was also successfully performed in spiked urine samples. A and MDMA in the presence of sucrose and as a content in illegally produced tablets were also determined. The voltammetric determinations of A and MDMA derivatives using CV and SWV at gold a electrode are rapid, selective and simple procedures and their accuracy was confirmed with a reference method, high performance liquid chromatography (HPLC). The analysis of spiked urine samples offers an additional possibility for the rapid detection of A and MDMA in human urine., Katalitička svojstva elektrode od zlata su testirana za kvantitativno određivanje amfetamina (A) i 3,4-metilendioksi-N-metilamfetamina (MDMA) standarda. Elektroksidacija A i MDMA je praćena cikličnom voltametrijom (CV). Vrednost oksidativnog pika A i MDMA standarda je linearna funkcija koncentracija u opsegu 110,9-258,9 μM (A) i 38,7-229,2 μM (MDMA). Voltametrija sa pravougaonim impulsima (SWV) je pokazala linearnu zavisnost struja od koncentracija za MDMA standard (u opsegu: 30,9-91,6 μM) kao i u spajkovanim uzorcima humanog urina. Uspešno je analiziran i sadržaj A i MDMA u ilegalno proizvedenim tabletama. Voltametrijsko određivanje A i MDMA derivata uz pomoć CV i SWV na elektrodi od zlata je brza, selektivna i jednostavna procedura. Analiza spajkovanih uzoraka urina nudi dodatnu mogućnost za brzu detekciju A i MDMA u humanom urinu.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine, Određivanje derivata amfetamina i primena u analizi humanog urina na elektrodi od zlata",
volume = "78",
number = "9",
pages = "1373-1385",
doi = "10.2298/JSC121228032N"
}
Nevescanin, M. M., Avramov Ivić, M., Petrović, S. D., Mijin, D., Stevic, S. N. B.,& Jovanović, V. M.. (2013). The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 78(9), 1373-1385.
https://doi.org/10.2298/JSC121228032N
Nevescanin MM, Avramov Ivić M, Petrović SD, Mijin D, Stevic SNB, Jovanović VM. The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine. in Journal of the Serbian Chemical Society. 2013;78(9):1373-1385.
doi:10.2298/JSC121228032N .
Nevescanin, Marina M., Avramov Ivić, Milka, Petrović, Slobodan D., Mijin, Dušan, Stevic, Sonja N. Banovic, Jovanović, Vladislava M., "The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine" in Journal of the Serbian Chemical Society, 78, no. 9 (2013):1373-1385,
https://doi.org/10.2298/JSC121228032N . .
