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dc.creatorMandić, Boris
dc.creatorSimić, Milena R.
dc.creatorVučković, Ivan
dc.creatorVujisić, Ljubodrag V.
dc.creatorNovaković, Miroslav
dc.creatorTrifunović, Snežana
dc.creatorNikolic-Mandic, Snezana D.
dc.creatorTešević, Vele
dc.creatorVajs, Vlatka
dc.creatorMilosavljević, Slobodan
dc.date.accessioned2019-01-30T17:35:27Z
dc.date.available2019-01-30T17:35:27Z
dc.date.issued2013
dc.identifier.issn1420-3049
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1241
dc.description.abstractThe examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.en
dc.publisherMDPI AG
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceMolecules
dc.subjectRindera umbellataen
dc.subjectpyrrolizidine alkaloidsen
dc.subjectfatty acidsen
dc.subjecttubulin polymerizationen
dc.titlePyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerizationen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractВујисиц, Љубодраг В.; Вајс, Влатка В.; Тесевиц, Веле В.; Мандиц, Борис М.; Николиц-Мандиц, Снезана Д.; Симиц, Милена Р.; Трифуновиц, Снезана С.; Новаковић, Мирослав; Милосављевиц, Слободан М.; Вуцковиц, Иван М.;
dc.citation.volume18
dc.citation.issue9
dc.citation.spage10694
dc.citation.epage10706
dc.citation.other18(9): 10694-10706
dc.citation.rankM22
dc.identifier.pmid24005964
dc.identifier.doi10.3390/molecules180910694
dc.identifier.rcubConv_3106
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/7753/1239.pdf
dc.identifier.scopus2-s2.0-84885140370
dc.identifier.wos000330306600041
dc.type.versionpublishedVersion


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