Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization
2013
Autori
Mandić, BorisSimić, Milena R.
Vučković, Ivan
Vujisić, Ljubodrag V.
Novaković, Miroslav
Trifunović, Snežana
Nikolic-Mandic, Snezana D.
Tešević, Vele
Vajs, Vlatka
Milosavljević, Slobodan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
Ključne reči:
Rindera umbellata / pyrrolizidine alkaloids / fatty acids / tubulin polymerizationIzvor:
Molecules, 2013, 18, 9, 10694-10706Izdavač:
- MDPI
Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-MESTD-Basic Research (BR or ON)-172053)
DOI: 10.3390/molecules180910694
ISSN: 1420-3049
PubMed: 24005964
WoS: 000330306600041
Scopus: 2-s2.0-84885140370
Institucija/grupa
IHTMTY - JOUR AU - Mandić, Boris AU - Simić, Milena R. AU - Vučković, Ivan AU - Vujisić, Ljubodrag V. AU - Novaković, Miroslav AU - Trifunović, Snežana AU - Nikolic-Mandic, Snezana D. AU - Tešević, Vele AU - Vajs, Vlatka AU - Milosavljević, Slobodan PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1241 AB - The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined. PB - MDPI T2 - Molecules T1 - Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization VL - 18 IS - 9 SP - 10694 EP - 10706 DO - 10.3390/molecules180910694 ER -
@article{ author = "Mandić, Boris and Simić, Milena R. and Vučković, Ivan and Vujisić, Ljubodrag V. and Novaković, Miroslav and Trifunović, Snežana and Nikolic-Mandic, Snezana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan", year = "2013", abstract = "The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.", publisher = "MDPI", journal = "Molecules", title = "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization", volume = "18", number = "9", pages = "10694-10706", doi = "10.3390/molecules180910694" }
Mandić, B., Simić, M. R., Vučković, I., Vujisić, L. V., Novaković, M., Trifunović, S., Nikolic-Mandic, S. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2013). Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules MDPI., 18(9), 10694-10706. https://doi.org/10.3390/molecules180910694
Mandić B, Simić MR, Vučković I, Vujisić LV, Novaković M, Trifunović S, Nikolic-Mandic SD, Tešević V, Vajs V, Milosavljević S. Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules. 2013;18(9):10694-10706. doi:10.3390/molecules180910694 .
Mandić, Boris, Simić, Milena R., Vučković, Ivan, Vujisić, Ljubodrag V., Novaković, Miroslav, Trifunović, Snežana, Nikolic-Mandic, Snezana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization" in Molecules, 18, no. 9 (2013):10694-10706, https://doi.org/10.3390/molecules180910694 . .