Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization

2013
Authors
Mandić, Boris
Simić, Milena R.

Vučković, Ivan

Vujisić, Ljubodrag V.

Novaković, Miroslav

Trifunović, Snežana

Nikolic-Mandic, Snezana D.

Tešević, Vele

Vajs, Vlatka
Milosavljević, Slobodan

Article (Published version)
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Show full item recordAbstract
The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
Keywords:
Rindera umbellata / pyrrolizidine alkaloids / fatty acids / tubulin polymerizationSource:
Molecules, 2013, 18, 9, 10694-10706Publisher:
- MDPI
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
DOI: 10.3390/molecules180910694
ISSN: 1420-3049
PubMed: 24005964
WoS: 000330306600041
Scopus: 2-s2.0-84885140370
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IHTMTY - JOUR AU - Mandić, Boris AU - Simić, Milena R. AU - Vučković, Ivan AU - Vujisić, Ljubodrag V. AU - Novaković, Miroslav AU - Trifunović, Snežana AU - Nikolic-Mandic, Snezana D. AU - Tešević, Vele AU - Vajs, Vlatka AU - Milosavljević, Slobodan PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1241 AB - The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined. PB - MDPI T2 - Molecules T1 - Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization VL - 18 IS - 9 SP - 10694 EP - 10706 DO - 10.3390/molecules180910694 ER -
@article{ author = "Mandić, Boris and Simić, Milena R. and Vučković, Ivan and Vujisić, Ljubodrag V. and Novaković, Miroslav and Trifunović, Snežana and Nikolic-Mandic, Snezana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan", year = "2013", abstract = "The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.", publisher = "MDPI", journal = "Molecules", title = "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization", volume = "18", number = "9", pages = "10694-10706", doi = "10.3390/molecules180910694" }
Mandić, B., Simić, M. R., Vučković, I., Vujisić, L. V., Novaković, M., Trifunović, S., Nikolic-Mandic, S. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2013). Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules MDPI., 18(9), 10694-10706. https://doi.org/10.3390/molecules180910694
Mandić B, Simić MR, Vučković I, Vujisić LV, Novaković M, Trifunović S, Nikolic-Mandic SD, Tešević V, Vajs V, Milosavljević S. Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules. 2013;18(9):10694-10706. doi:10.3390/molecules180910694 .
Mandić, Boris, Simić, Milena R., Vučković, Ivan, Vujisić, Ljubodrag V., Novaković, Miroslav, Trifunović, Snežana, Nikolic-Mandic, Snezana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization" in Molecules, 18, no. 9 (2013):10694-10706, https://doi.org/10.3390/molecules180910694 . .