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Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization

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2013
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Authors
Mandić, Boris
Simić, Milena R.
Vučković, Ivan
Vujisić, Ljubodrag V.
Novaković, Miroslav
Trifunović, Snežana
Nikolic-Mandic, Snezana D.
Tešević, Vele
Vajs, Vlatka
Milosavljević, Slobodan
Article (Published version)
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Abstract
The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
Keywords:
Rindera umbellata / pyrrolizidine alkaloids / fatty acids / tubulin polymerization
Source:
Molecules, 2013, 18, 9, 10694-10706
Publisher:
  • Mdpi Ag, Basel
Projects:
  • Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)

DOI: 10.3390/molecules180910694

ISSN: 1420-3049

PubMed: 24005964

WoS: 000330306600041

Scopus: 2-s2.0-84885140370
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1241
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