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Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization

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2013
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Authors
Mandić, Boris
Simić, Milena R.
Vučković, Ivan
Vujisić, Ljubodrag V.
Novaković, Miroslav
Trifunović, Snežana
Nikolic-Mandic, Snezana D.
Tešević, Vele
Vajs, Vlatka
Milosavljević, Slobodan
Article (Published version)
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Abstract
The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
Keywords:
Rindera umbellata / pyrrolizidine alkaloids / fatty acids / tubulin polymerization
Source:
Molecules, 2013, 18, 9, 10694-10706
Publisher:
  • MDPI
Funding / projects:
  • Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)

DOI: 10.3390/molecules180910694

ISSN: 1420-3049

PubMed: 24005964

WoS: 000330306600041

Scopus: 2-s2.0-84885140370
[ Google Scholar ]
14
9
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/1241
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Mandić, Boris
AU  - Simić, Milena R.
AU  - Vučković, Ivan
AU  - Vujisić, Ljubodrag V.
AU  - Novaković, Miroslav
AU  - Trifunović, Snežana
AU  - Nikolic-Mandic, Snezana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1241
AB  - The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
PB  - MDPI
T2  - Molecules
T1  - Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization
VL  - 18
IS  - 9
SP  - 10694
EP  - 10706
DO  - 10.3390/molecules180910694
ER  - 
@article{
author = "Mandić, Boris and Simić, Milena R. and Vučković, Ivan and Vujisić, Ljubodrag V. and Novaković, Miroslav and Trifunović, Snežana and Nikolic-Mandic, Snezana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2013",
abstract = "The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.",
publisher = "MDPI",
journal = "Molecules",
title = "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization",
volume = "18",
number = "9",
pages = "10694-10706",
doi = "10.3390/molecules180910694"
}
Mandić, B., Simić, M. R., Vučković, I., Vujisić, L. V., Novaković, M., Trifunović, S., Nikolic-Mandic, S. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2013). Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules
MDPI., 18(9), 10694-10706.
https://doi.org/10.3390/molecules180910694
Mandić B, Simić MR, Vučković I, Vujisić LV, Novaković M, Trifunović S, Nikolic-Mandic SD, Tešević V, Vajs V, Milosavljević S. Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules. 2013;18(9):10694-10706.
doi:10.3390/molecules180910694 .
Mandić, Boris, Simić, Milena R., Vučković, Ivan, Vujisić, Ljubodrag V., Novaković, Miroslav, Trifunović, Snežana, Nikolic-Mandic, Snezana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization" in Molecules, 18, no. 9 (2013):10694-10706,
https://doi.org/10.3390/molecules180910694 . .

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