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dc.creatorLugonja, Nikoleta
dc.creatorSpasić, Snežana
dc.creatorLaugier, Olga B.
dc.creatorNikolić-Kokić, Aleksandra
dc.creatorSpasojević, Ivan
dc.creatorOrescanin-Dusic, Zorana
dc.creatorVrvić, Miroslav
dc.date.accessioned2019-01-30T17:35:25Z
dc.date.available2019-01-30T17:35:25Z
dc.date.issued2013
dc.identifier.issn0899-9007
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1238
dc.description.abstractObjective: Early-onset and exclusive breast-feeding provides a significant health benefit to infants compared with infant formulas. The aim of this study was to compare mature breast milk with standard infant formulas by examining their effects on non-vascular smooth muscle contraction and their antioxidative properties. Methods: The pharmacologic effects of breast milk and formulas were examined using a model system of the rat uterine smooth muscle contraction. Electron paramagnetic resonance spin-trapping spectroscopy was used to compare the antioxidative capacities of breast milk (obtained in the ninth week of lactation) with commercial infant formulas against hydroxyl radical production in the Fenton reaction. The activities of superoxide dismutase, glutathione peroxidase, and the sulfhydryl group were determined in the breast milk and infant formulas. Results: In contrast to the infant formulas, breast milk exerted a relaxing effect on isolated non-vascular smooth muscle. In general, breast milk showed higher antioxidative activity compared with the infant formulas. In all samples, the generation of hydroxyl radicals led to the formation of carbon-centered and ascorbyl radicals. Conclusions: Human milk exerts direct pharmacologic relaxation effects and provides better antioxidant protection compared with infant formulas because of the presence of specific enzymatic components, such as human superoxide dismutase. We propose that these effects should be advantageous to an infant's gastrointestinal tract by supporting the normal work of the smooth musculature and maintaining redox homeostasis and may represent one of the mechanisms by which breast-feeding benefits health.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//
dc.rightsrestrictedAccess
dc.sourceNutrition
dc.subjectBreast milken
dc.subjectInfant formulaen
dc.subjectElectron paramagnetic resonanceen
dc.subjectSuperoxide dismutaseen
dc.subjectGlutathione peroxidaseen
dc.subjectSulfhydryl groupen
dc.titleDifferences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulasen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСпасојевиц, Иван; Лугоња, Николета; Николиц-Кокиц, Aлександра; Врвиц, Мирослав М.; Лаугиер, Олга; Оресцанин-Дусиц, Зорана; Спасић, Снежана;
dc.citation.volume29
dc.citation.issue2
dc.citation.spage431
dc.citation.epage435
dc.citation.other29(2): 431-435
dc.citation.rankM22
dc.identifier.pmid23312765
dc.identifier.doi10.1016/j.nut.2012.07.018
dc.identifier.rcubConv_2752
dc.identifier.scopus2-s2.0-84872255665
dc.identifier.wos000314443600011
dc.type.versionpublishedVersion


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