Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas
Samo za registrovane korisnike
2013
Autori
Lugonja, NikoletaSpasić, Snežana
Laugier, Olga B.
Nikolić-Kokić, Aleksandra
Spasojević, Ivan
Oreščanin-Dušić, Zorana
Vrvić, Miroslav
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Objective: Early-onset and exclusive breast-feeding provides a significant health benefit to infants compared with infant formulas. The aim of this study was to compare mature breast milk with standard infant formulas by examining their effects on non-vascular smooth muscle contraction and their antioxidative properties. Methods: The pharmacologic effects of breast milk and formulas were examined using a model system of the rat uterine smooth muscle contraction. Electron paramagnetic resonance spin-trapping spectroscopy was used to compare the antioxidative capacities of breast milk (obtained in the ninth week of lactation) with commercial infant formulas against hydroxyl radical production in the Fenton reaction. The activities of superoxide dismutase, glutathione peroxidase, and the sulfhydryl group were determined in the breast milk and infant formulas. Results: In contrast to the infant formulas, breast milk exerted a relaxing effect on isolated non-vascular smooth muscle. In gener...al, breast milk showed higher antioxidative activity compared with the infant formulas. In all samples, the generation of hydroxyl radicals led to the formation of carbon-centered and ascorbyl radicals. Conclusions: Human milk exerts direct pharmacologic relaxation effects and provides better antioxidant protection compared with infant formulas because of the presence of specific enzymatic components, such as human superoxide dismutase. We propose that these effects should be advantageous to an infant's gastrointestinal tract by supporting the normal work of the smooth musculature and maintaining redox homeostasis and may represent one of the mechanisms by which breast-feeding benefits health.
Ključne reči:
Breast milk / Infant formula / Electron paramagnetic resonance / Superoxide dismutase / Glutathione peroxidase / Sulfhydryl groupIzvor:
Nutrition, 2013, 29, 2, 431-435Izdavač:
- Elsevier Science Inc, New York
Finansiranje / projekti:
- Simultana bioremedijacija i soilifikacija degradiranih prostora, za očuvanje prirodnih resursa biološki aktivnih supstanci i razvoj i proizvodnju biomaterijala i dijetetskih proizvoda (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
- Molekularni mehanizmi redoks signalinga u homeostazi, adaptaciji i patologiji (RS-MESTD-Basic Research (BR or ON)-173014)
DOI: 10.1016/j.nut.2012.07.018
ISSN: 0899-9007
PubMed: 23312765
WoS: 000314443600011
Scopus: 2-s2.0-84872255665
Institucija/grupa
IHTMTY - JOUR AU - Lugonja, Nikoleta AU - Spasić, Snežana AU - Laugier, Olga B. AU - Nikolić-Kokić, Aleksandra AU - Spasojević, Ivan AU - Oreščanin-Dušić, Zorana AU - Vrvić, Miroslav PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1238 AB - Objective: Early-onset and exclusive breast-feeding provides a significant health benefit to infants compared with infant formulas. The aim of this study was to compare mature breast milk with standard infant formulas by examining their effects on non-vascular smooth muscle contraction and their antioxidative properties. Methods: The pharmacologic effects of breast milk and formulas were examined using a model system of the rat uterine smooth muscle contraction. Electron paramagnetic resonance spin-trapping spectroscopy was used to compare the antioxidative capacities of breast milk (obtained in the ninth week of lactation) with commercial infant formulas against hydroxyl radical production in the Fenton reaction. The activities of superoxide dismutase, glutathione peroxidase, and the sulfhydryl group were determined in the breast milk and infant formulas. Results: In contrast to the infant formulas, breast milk exerted a relaxing effect on isolated non-vascular smooth muscle. In general, breast milk showed higher antioxidative activity compared with the infant formulas. In all samples, the generation of hydroxyl radicals led to the formation of carbon-centered and ascorbyl radicals. Conclusions: Human milk exerts direct pharmacologic relaxation effects and provides better antioxidant protection compared with infant formulas because of the presence of specific enzymatic components, such as human superoxide dismutase. We propose that these effects should be advantageous to an infant's gastrointestinal tract by supporting the normal work of the smooth musculature and maintaining redox homeostasis and may represent one of the mechanisms by which breast-feeding benefits health. PB - Elsevier Science Inc, New York T2 - Nutrition T1 - Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas VL - 29 IS - 2 SP - 431 EP - 435 DO - 10.1016/j.nut.2012.07.018 ER -
@article{ author = "Lugonja, Nikoleta and Spasić, Snežana and Laugier, Olga B. and Nikolić-Kokić, Aleksandra and Spasojević, Ivan and Oreščanin-Dušić, Zorana and Vrvić, Miroslav", year = "2013", abstract = "Objective: Early-onset and exclusive breast-feeding provides a significant health benefit to infants compared with infant formulas. The aim of this study was to compare mature breast milk with standard infant formulas by examining their effects on non-vascular smooth muscle contraction and their antioxidative properties. Methods: The pharmacologic effects of breast milk and formulas were examined using a model system of the rat uterine smooth muscle contraction. Electron paramagnetic resonance spin-trapping spectroscopy was used to compare the antioxidative capacities of breast milk (obtained in the ninth week of lactation) with commercial infant formulas against hydroxyl radical production in the Fenton reaction. The activities of superoxide dismutase, glutathione peroxidase, and the sulfhydryl group were determined in the breast milk and infant formulas. Results: In contrast to the infant formulas, breast milk exerted a relaxing effect on isolated non-vascular smooth muscle. In general, breast milk showed higher antioxidative activity compared with the infant formulas. In all samples, the generation of hydroxyl radicals led to the formation of carbon-centered and ascorbyl radicals. Conclusions: Human milk exerts direct pharmacologic relaxation effects and provides better antioxidant protection compared with infant formulas because of the presence of specific enzymatic components, such as human superoxide dismutase. We propose that these effects should be advantageous to an infant's gastrointestinal tract by supporting the normal work of the smooth musculature and maintaining redox homeostasis and may represent one of the mechanisms by which breast-feeding benefits health.", publisher = "Elsevier Science Inc, New York", journal = "Nutrition", title = "Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas", volume = "29", number = "2", pages = "431-435", doi = "10.1016/j.nut.2012.07.018" }
Lugonja, N., Spasić, S., Laugier, O. B., Nikolić-Kokić, A., Spasojević, I., Oreščanin-Dušić, Z.,& Vrvić, M.. (2013). Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas. in Nutrition Elsevier Science Inc, New York., 29(2), 431-435. https://doi.org/10.1016/j.nut.2012.07.018
Lugonja N, Spasić S, Laugier OB, Nikolić-Kokić A, Spasojević I, Oreščanin-Dušić Z, Vrvić M. Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas. in Nutrition. 2013;29(2):431-435. doi:10.1016/j.nut.2012.07.018 .
Lugonja, Nikoleta, Spasić, Snežana, Laugier, Olga B., Nikolić-Kokić, Aleksandra, Spasojević, Ivan, Oreščanin-Dušić, Zorana, Vrvić, Miroslav, "Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas" in Nutrition, 29, no. 2 (2013):431-435, https://doi.org/10.1016/j.nut.2012.07.018 . .