The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HP beta CD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HP beta CD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both el...ectrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased.
TY - JOUR
AU - Stoiljković, Zora
AU - Jovanović, Vladislava M.
AU - Mijin, Dušan
AU - Nikolić, V.
AU - Nikolic, Lj.
AU - Petrović, Slobodan D.
AU - Avramov Ivić, Milka
PY - 2013
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1221
AB - The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HP beta CD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HP beta CD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both electrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased.
PB - Esg, Belgrade
T2 - International Journal of Electrochemical Science
T1 - The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin
VL - 8
IS - 7
SP - 9543
EP - 9557
UR - https://hdl.handle.net/21.15107/rcub_cer_1221
ER -
@article{
author = "Stoiljković, Zora and Jovanović, Vladislava M. and Mijin, Dušan and Nikolić, V. and Nikolic, Lj. and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2013",
abstract = "The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HP beta CD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HP beta CD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both electrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased.",
publisher = "Esg, Belgrade",
journal = "International Journal of Electrochemical Science",
title = "The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin",
volume = "8",
number = "7",
pages = "9543-9557",
url = "https://hdl.handle.net/21.15107/rcub_cer_1221"
}
Stoiljković, Z., Jovanović, V. M., Mijin, D., Nikolić, V., Nikolic, Lj., Petrović, S. D.,& Avramov Ivić, M.. (2013). The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin. in International Journal of Electrochemical Science
Esg, Belgrade., 8(7), 9543-9557.
https://hdl.handle.net/21.15107/rcub_cer_1221
Stoiljković Z, Jovanović VM, Mijin D, Nikolić V, Nikolic L, Petrović SD, Avramov Ivić M. The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin. in International Journal of Electrochemical Science. 2013;8(7):9543-9557.
https://hdl.handle.net/21.15107/rcub_cer_1221 .
Stoiljković, Zora, Jovanović, Vladislava M., Mijin, Dušan, Nikolić, V., Nikolic, Lj., Petrović, Slobodan D., Avramov Ivić, Milka, "The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin" in International Journal of Electrochemical Science, 8, no. 7 (2013):9543-9557,
https://hdl.handle.net/21.15107/rcub_cer_1221 .
