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dc.creatorZarić, Božidarka
dc.creatorBukorović, Milica
dc.creatorStojanović, Srđan
dc.date.accessioned2019-01-30T17:34:49Z
dc.date.available2019-01-30T17:34:49Z
dc.date.issued2013
dc.identifier.issn1842-3582
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1210
dc.description.abstractThe Sm and Sm-like (LSm) proteins are a widespread protein family with members in all kingdoms of life. Sm proteins form complexes engaging in various RNA-processing events. Sm proteins do form and act as oligomeric assemblies whose characteristic is their exceptional stability. This study compares strong and weak hydrogen bonds in the interior of monomers and at interfaces of Sm/LSm proteins in order to better understand the stability of oligomers. According to our results, the stability of oligomeric assemblies is achieved by CH center dot center dot center dot O, NH center dot center dot center dot O and CH center dot center dot center dot N interactions including, NH center dot center dot center dot N, OH center dot center dot center dot O, XH center dot center dot center dot pi interactions present in small percentages. Intrachain hydrogen bonds behave in respect to geometry, distances and angles, like interchain hydrogen bonds. It is also shown that amino acids Arg and Lys participate significantly as donors or acceptors in some of the strong or weak interactions at interfaces to a higher extent than in the monomers. There is a trend for most polar amino acids to cross into more solvent exposed position in interfaces, which is not the case for nonpolar or charged amino acids. There is no exclusive preference for particular secondary structure both for intrachains and for interfaces.en
dc.publisherInst Materials Physics, Bucharest
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172001/RS//
dc.rightsrestrictedAccess
dc.sourceDigest Journal of Nanomaterials and Biostructures
dc.subjectSm/LSm proteinsen
dc.subjectHydrogen bondsen
dc.subjectSecondary structure preferencesen
dc.subjectSolvent accessibilityen
dc.titleStrong and weak hydrogen bonds in sm/lsm oligomeric assemblies: a comparison of intra- and interchain interactionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗариц, Бозидарка Л.; Букоровиц, Милица В.; Стојановић, Срђан;
dc.citation.volume8
dc.citation.issue2
dc.citation.spage639
dc.citation.epage654
dc.citation.other8(2): 639-654
dc.citation.rankM22
dc.identifier.rcubConv_3010
dc.identifier.scopus2-s2.0-84876485069
dc.identifier.wos000322737500017
dc.type.versionpublishedVersion


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