Current advances in research of cytochrome c oxidase
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2013
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Prikaz svih podataka o dokumentuApstrakt
The function of cytochrome c oxidase as a biomolecular nanomachine that transforms energy of redox reaction into protonmotive force across a biological membrane has been subject of intense research, debate, and controversy. The structure of the enzyme has been solved for several organisms; however details of its molecular mechanism of proton pumping still remain elusive. Particularly, the identity of the proton pumping site, the key element of the mechanism, is still open to dispute. The pumping mechanism has been for a long time one of the key unsolved issues of bioenergetics and biochemistry, but with the accelerating progress in this field many important details and principles have emerged. Current advances in cytochrome oxidase research are reviewed here, along with a brief discussion of the most complete proton pumping mechanism proposed to date, and a molecular basis for control of its efficiency.
Ključne reči:
Cytochrome c oxidase / Proton pumping mechanism / Kinetic control / Proton-coupled electron transfer / Catalytic cycle / Bioenergetics / Redox-driven proton pumpIzvor:
Amino Acids, 2013, 45, 5, 1073-1087Izdavač:
- Springer Wien, Wien
Finansiranje / projekti:
DOI: 10.1007/s00726-013-1585-y
ISSN: 0939-4451
PubMed: 23999646
WoS: 000325813800005
Scopus: 2-s2.0-84886288179
Institucija/grupa
IHTMTY - JOUR AU - Popović, Dragan PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1195 AB - The function of cytochrome c oxidase as a biomolecular nanomachine that transforms energy of redox reaction into protonmotive force across a biological membrane has been subject of intense research, debate, and controversy. The structure of the enzyme has been solved for several organisms; however details of its molecular mechanism of proton pumping still remain elusive. Particularly, the identity of the proton pumping site, the key element of the mechanism, is still open to dispute. The pumping mechanism has been for a long time one of the key unsolved issues of bioenergetics and biochemistry, but with the accelerating progress in this field many important details and principles have emerged. Current advances in cytochrome oxidase research are reviewed here, along with a brief discussion of the most complete proton pumping mechanism proposed to date, and a molecular basis for control of its efficiency. PB - Springer Wien, Wien T2 - Amino Acids T1 - Current advances in research of cytochrome c oxidase VL - 45 IS - 5 SP - 1073 EP - 1087 DO - 10.1007/s00726-013-1585-y ER -
@article{ author = "Popović, Dragan", year = "2013", abstract = "The function of cytochrome c oxidase as a biomolecular nanomachine that transforms energy of redox reaction into protonmotive force across a biological membrane has been subject of intense research, debate, and controversy. The structure of the enzyme has been solved for several organisms; however details of its molecular mechanism of proton pumping still remain elusive. Particularly, the identity of the proton pumping site, the key element of the mechanism, is still open to dispute. The pumping mechanism has been for a long time one of the key unsolved issues of bioenergetics and biochemistry, but with the accelerating progress in this field many important details and principles have emerged. Current advances in cytochrome oxidase research are reviewed here, along with a brief discussion of the most complete proton pumping mechanism proposed to date, and a molecular basis for control of its efficiency.", publisher = "Springer Wien, Wien", journal = "Amino Acids", title = "Current advances in research of cytochrome c oxidase", volume = "45", number = "5", pages = "1073-1087", doi = "10.1007/s00726-013-1585-y" }
Popović, D.. (2013). Current advances in research of cytochrome c oxidase. in Amino Acids Springer Wien, Wien., 45(5), 1073-1087. https://doi.org/10.1007/s00726-013-1585-y
Popović D. Current advances in research of cytochrome c oxidase. in Amino Acids. 2013;45(5):1073-1087. doi:10.1007/s00726-013-1585-y .
Popović, Dragan, "Current advances in research of cytochrome c oxidase" in Amino Acids, 45, no. 5 (2013):1073-1087, https://doi.org/10.1007/s00726-013-1585-y . .