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Current advances in research of cytochrome c oxidase

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2013
Authors
Popović, Dragan
Article (Published version)
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Abstract
The function of cytochrome c oxidase as a biomolecular nanomachine that transforms energy of redox reaction into protonmotive force across a biological membrane has been subject of intense research, debate, and controversy. The structure of the enzyme has been solved for several organisms; however details of its molecular mechanism of proton pumping still remain elusive. Particularly, the identity of the proton pumping site, the key element of the mechanism, is still open to dispute. The pumping mechanism has been for a long time one of the key unsolved issues of bioenergetics and biochemistry, but with the accelerating progress in this field many important details and principles have emerged. Current advances in cytochrome oxidase research are reviewed here, along with a brief discussion of the most complete proton pumping mechanism proposed to date, and a molecular basis for control of its efficiency.
Keywords:
Cytochrome c oxidase / Proton pumping mechanism / Kinetic control / Proton-coupled electron transfer / Catalytic cycle / Bioenergetics / Redox-driven proton pump
Source:
Amino Acids, 2013, 45, 5, 1073-1087
Publisher:
  • Springer Wien, Wien
Funding / projects:
  • Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)

DOI: 10.1007/s00726-013-1585-y

ISSN: 0939-4451

PubMed: 23999646

WoS: 000325813800005

Scopus: 2-s2.0-84886288179
[ Google Scholar ]
21
14
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/1195
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Popović, Dragan
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1195
AB  - The function of cytochrome c oxidase as a biomolecular nanomachine that transforms energy of redox reaction into protonmotive force across a biological membrane has been subject of intense research, debate, and controversy. The structure of the enzyme has been solved for several organisms; however details of its molecular mechanism of proton pumping still remain elusive. Particularly, the identity of the proton pumping site, the key element of the mechanism, is still open to dispute. The pumping mechanism has been for a long time one of the key unsolved issues of bioenergetics and biochemistry, but with the accelerating progress in this field many important details and principles have emerged. Current advances in cytochrome oxidase research are reviewed here, along with a brief discussion of the most complete proton pumping mechanism proposed to date, and a molecular basis for control of its efficiency.
PB  - Springer Wien, Wien
T2  - Amino Acids
T1  - Current advances in research of cytochrome c oxidase
VL  - 45
IS  - 5
SP  - 1073
EP  - 1087
DO  - 10.1007/s00726-013-1585-y
ER  - 
@article{
author = "Popović, Dragan",
year = "2013",
abstract = "The function of cytochrome c oxidase as a biomolecular nanomachine that transforms energy of redox reaction into protonmotive force across a biological membrane has been subject of intense research, debate, and controversy. The structure of the enzyme has been solved for several organisms; however details of its molecular mechanism of proton pumping still remain elusive. Particularly, the identity of the proton pumping site, the key element of the mechanism, is still open to dispute. The pumping mechanism has been for a long time one of the key unsolved issues of bioenergetics and biochemistry, but with the accelerating progress in this field many important details and principles have emerged. Current advances in cytochrome oxidase research are reviewed here, along with a brief discussion of the most complete proton pumping mechanism proposed to date, and a molecular basis for control of its efficiency.",
publisher = "Springer Wien, Wien",
journal = "Amino Acids",
title = "Current advances in research of cytochrome c oxidase",
volume = "45",
number = "5",
pages = "1073-1087",
doi = "10.1007/s00726-013-1585-y"
}
Popović, D.. (2013). Current advances in research of cytochrome c oxidase. in Amino Acids
Springer Wien, Wien., 45(5), 1073-1087.
https://doi.org/10.1007/s00726-013-1585-y
Popović D. Current advances in research of cytochrome c oxidase. in Amino Acids. 2013;45(5):1073-1087.
doi:10.1007/s00726-013-1585-y .
Popović, Dragan, "Current advances in research of cytochrome c oxidase" in Amino Acids, 45, no. 5 (2013):1073-1087,
https://doi.org/10.1007/s00726-013-1585-y . .

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