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dc.creatorDordevic, Sanela M.
dc.creatorRadulovic, Tamara S.
dc.creatorCekic, Nebojsa
dc.creatorRanđelović, Danijela
dc.creatorSavić, Miroslav M.
dc.creatorKrajisnik, Danina R.
dc.creatorMilic, Jela R.
dc.creatorSavić, Snežana D.
dc.date.accessioned2019-01-30T17:34:33Z
dc.date.available2019-01-30T17:34:33Z
dc.date.issued2013
dc.identifier.issn0022-3549
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1194
dc.description.abstractWith the aid of experimental design, we developed and characterized nanoemulsions for parenteral drug delivery. Formulations containing a mixture of medium-chain triglycerides and soybean oil as oil phase, lecithin (soybean/egg) and polysorbate 80 as emulsifiers, and 0.1M phosphate buffer solution (pH 8) as aqueous phase were prepared by cold high-pressure homogenization. To study the effects of the oil content, lecithin type, and the presence of diazepam as a model drug and their interactions on physicochemical characteristics of nanoemulsions, a three factor two-level full factorial design was applied. The nanoemulsions were evaluated concerning droplet size and size distribution, surface charge, viscosity, morphology, drug-excipient interactions, and physical stability. The characterization revealed the small spherical droplets in the range 195-220nm with polydispersity index below 0.15 and zeta potential between -30 and -60mV. Interactions among the investigated factors, rather than factors alone, were shown to more profoundly affect nanoemulsion characteristics. In vivo pharmacokinetic study of selected diazepam nanoemulsions with different oil content (20%, 30%, and 40%, w/w) demonstrated fast and intense initial distribution into rat brain of diazepam from nanoemulsions with 20% and 30% (w/w) oil content, suggesting their applicability in urgent situations.en
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175076/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/32008/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical Sciences
dc.subjectnanoemulsionen
dc.subjectdiazepamen
dc.subjectfull factorial designen
dc.subjectparticle sizeen
dc.subjectatomic force microscopyen
dc.subjectFTIRen
dc.subjectdrug-excipient interactionen
dc.subjectstabilityen
dc.subjectpharmacokineticsen
dc.titleExperimental Design in Formulation of Diazepam Nanoemulsions: Physicochemical and Pharmacokinetic Performancesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦекиц, Небојса Д.; Радуловиц, Тамара С.; Савиц, Мирослав М.; Савиц, Снезана Д.; Дордевиц, Санела М.; Ранђеловић, Данијела; Милиц, Јела Р.; Крајисник, Данина Р.;
dc.citation.volume102
dc.citation.issue11
dc.citation.spage4159
dc.citation.epage4172
dc.citation.other102(11): 4159-4172
dc.citation.rankM21
dc.identifier.pmid24114833
dc.identifier.doi10.1002/jps.23734
dc.identifier.rcubConv_3045
dc.identifier.scopus2-s2.0-84885846550
dc.identifier.wos000325550400032
dc.type.versionpublishedVersion


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