Antimalarial, antimycobacterial and antiproliferative activity of phenyl substituted mixed tetraoxanes
Antimalarijska, antimikobakterijska i antiproliferativna aktivnost fenil-supstituisanih tetraoksana
dc.creator | Opsenica, Dejan | |
dc.creator | Dennis, Kyle E. | |
dc.creator | Milhous, Wilbur K. | |
dc.creator | Šolaja, Bogdan | |
dc.date.accessioned | 2019-01-30T17:11:26Z | |
dc.date.available | 2019-01-30T17:11:26Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/116 | |
dc.description.abstract | Mixed tetraoxanes of the 4"-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl- spirocholate series have been prepared and evaluated as possible antimalarials, antiproliferatives and antimycobacterials. The activity of the (4"R or S)-phenyl series against P. falciparum D6 and W2 strains was found to be at the level of artemisinin with two compounds, the acid 4 and the amide 6, exhibiting encouraging anti-TB activity as well. Very promising in vitro results of the said tetraoxanes were obtained against solid tumours and, in some instances, the activity against a selected number of cell lines was higher than that of the antitumor drug Paclitaxel. | en |
dc.description.abstract | U ovom radu prikazana je sinteza serije mešovitih tetraoksana 4"-fenil-supstituisanih cikloheksil-spirotetraoksacikloheksil-spiroholata, a ispitana je i njihova in vitro aktivnost kao mogućih antimalarika, anti-TBC agenasa i antiproliferativnih jedinjenja. Aktivnost (4"R ili S)-fenil serije na D6 i W2 sojeve P. falciparum vrlo je slična aktivnosti poznatog antimalarika artemizinina. Izraženu anti-TBC aktivnost iskazala su jedinjenja 4 i 6, čija antiproliferativna in vitro aktivnost prema nekim kompaktnim tumorima prevazilazi aktivnost leka paklitaksela. | sr |
dc.publisher | Serbian Chemical Society | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | mixed tetraoxane | en |
dc.subject | malaria | en |
dc.subject | tuberculosis | en |
dc.subject | cancer | en |
dc.subject | peroxide | en |
dc.subject | steroid | en |
dc.title | Antimalarial, antimycobacterial and antiproliferative activity of phenyl substituted mixed tetraoxanes | en |
dc.title | Antimalarijska, antimikobakterijska i antiproliferativna aktivnost fenil-supstituisanih tetraoksana | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Деннис, Кyле Е.; Шолаја, Богдан A.; Опсеница, Дејан; Wилбур, Милхоус К.; Aнтималаријска, антимикобактеријска и антипролиферативна активност фенил-супституисаних тетраоксана; Aнтималаријска, антимикобактеријска и антипролиферативна активност фенил-супституисаних тетраоксана; | |
dc.citation.volume | 68 | |
dc.citation.issue | 4-5 | |
dc.citation.spage | 291 | |
dc.citation.epage | 302 | |
dc.citation.other | 68(4-5): 291-302 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.2298/JSC0305291O | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/7681/114.pdf | |
dc.identifier.scopus | 2-s2.0-0037835603 | |
dc.identifier.wos | 000183423800008 | |
dc.type.version | publishedVersion |