Show simple item record

Antimalarijska, antimikobakterijska i antiproliferativna aktivnost fenil-supstituisanih tetraoksana

dc.creatorOpsenica, Dejan
dc.creatorDennis, Kyle E.
dc.creatorMilhous, Wilbur K.
dc.creatorŠolaja, Bogdan
dc.date.accessioned2019-01-30T17:11:26Z
dc.date.available2019-01-30T17:11:26Z
dc.date.issued2003
dc.identifier.issn0352-5139
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/116
dc.description.abstractMixed tetraoxanes of the 4"-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl- spirocholate series have been prepared and evaluated as possible antimalarials, antiproliferatives and antimycobacterials. The activity of the (4"R or S)-phenyl series against P. falciparum D6 and W2 strains was found to be at the level of artemisinin with two compounds, the acid 4 and the amide 6, exhibiting encouraging anti-TB activity as well. Very promising in vitro results of the said tetraoxanes were obtained against solid tumours and, in some instances, the activity against a selected number of cell lines was higher than that of the antitumor drug Paclitaxel.en
dc.description.abstractU ovom radu prikazana je sinteza serije mešovitih tetraoksana 4"-fenil-supstituisanih cikloheksil-spirotetraoksacikloheksil-spiroholata, a ispitana je i njihova in vitro aktivnost kao mogućih antimalarika, anti-TBC agenasa i antiproliferativnih jedinjenja. Aktivnost (4"R ili S)-fenil serije na D6 i W2 sojeve P. falciparum vrlo je slična aktivnosti poznatog antimalarika artemizinina. Izraženu anti-TBC aktivnost iskazala su jedinjenja 4 i 6, čija antiproliferativna in vitro aktivnost prema nekim kompaktnim tumorima prevazilazi aktivnost leka paklitaksela.sr
dc.publisherSerbian Chemical Society
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectmixed tetraoxaneen
dc.subjectmalariaen
dc.subjecttuberculosisen
dc.subjectcanceren
dc.subjectperoxideen
dc.subjectsteroiden
dc.titleAntimalarial, antimycobacterial and antiproliferative activity of phenyl substituted mixed tetraoxanesen
dc.titleAntimalarijska, antimikobakterijska i antiproliferativna aktivnost fenil-supstituisanih tetraoksanasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractДеннис, Кyле Е.; Шолаја, Богдан A.; Опсеница, Дејан; Wилбур, Милхоус К.; Aнтималаријска, антимикобактеријска и антипролиферативна активност фенил-супституисаних тетраоксана; Aнтималаријска, антимикобактеријска и антипролиферативна активност фенил-супституисаних тетраоксана;
dc.citation.volume68
dc.citation.issue4-5
dc.citation.spage291
dc.citation.epage302
dc.citation.other68(4-5): 291-302
dc.citation.rankM23
dc.identifier.doi10.2298/JSC0305291O
dc.identifier.rcubConv_169
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/7681/114.pdf
dc.identifier.scopus2-s2.0-0037835603
dc.identifier.wos000183423800008
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record