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Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro

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2012
1934578x1200701119.pdf (266.9Kb)
Authors
Balijagic, Jasmina
Janković, Teodora
Zdunić, Gordana
Boskovic, Jelena
Savikin, Katarina
Gođevac, Dejan
Stanojković, Tatjana
Jovancevic, Miodrag
Menković, Nebojša
Article (Published version)
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Abstract
LC-ESI-MS and HPLC were used for the identification of the constituents from G. lutea leaves collected at different localities, as well as for quantification of the main compounds. Seven secoiridoids, five C-glucoflavones and three xanthones, were identified. Swertiamarin derivatives, namely eustornorusside (2), eustomoside (3) and septemfidoside (5), were detected in G. lutea for the first time. Concentrations of five constituents (swertiamarin, gentiopicrin, isovitexin, mangiferin and isogentisin) were determined. The relationship between concentrations of gamma-pyrones and altitude was observed with statistically significant correlation (r = 0.94). The extracts were also evaluated for their content of total phenolics, and antiradical and cytotoxic activities. The total phenolics content ranged from 7.7 to 12.7 mg GAE/g, and the IC50 values for DPPH radical scavenging activity varied between 0.45 to 2.02 mg/mL. The leaf extract exhibited moderate cytotoxic effects toward HeLa cells w...ith an IC50 value of 41.1 mu g/mL, while gentiopicrin, mangiferin and isogentisin exerted strong activity against HeLa cells, with IC50 values ranging from 5.7 to 8.8 mu g/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents.

Keywords:
Gentiana lutea leaves / Secoiridoids / Flavonoids / cytotoxicity
Source:
Natural Product Communications, 2012, 7, 11, 1487-1490
Publisher:
  • Natural Products Inc, Westerville
Projects:
  • Traditional and new products of cultivated and wild growing fruits and grape vines, and by-products durring processing, with special emphasis on indigenous varieties: chemical characterization and biological profile (RS-46013)

ISSN: 1934-578X

PubMed: 23285813

WoS: 000311663700019

Scopus: 2-s2.0-84869814610
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1122
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  • Radovi istraživača / Researchers' publications
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