Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
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2012
Authors
Kaluđerović, Goran N.
Mijatović, Sanja

Zmejkovski, Bojana

Bulatović, Mirna

Gómez-Ruiz, Santiago

Mojic, Marija K.

Steinborn, Dirk
Miljkovic, Djordje M.

Schmidt, Harry
Stosic-Grujicic, Stanislava D.

Sabo, Tibor

Maksimović-Ivanić, Danijela D.

Article (Published version)

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Show full item recordAbstract
Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
Source:
Metallomics, 2012, 4, 9, 979-987Publisher:
- Royal Soc Chemistry, Cambridge
Projects:
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)
- Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (RS-173013)
- Alexander von Humboldt Foundation (Germany)
DOI: 10.1039/c2mt20058a
ISSN: 1756-5901
PubMed: 22820831