CER - Central Repository
Institute of Chemistry, Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   Central Repository
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
  •   Central Repository
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells

Authorized Users Only
2012
Authors
Kaluđerović, Goran N.
Mijatović, Sanja
Zmejkovski, Bojana
Bulatović, Mirna
Gómez-Ruiz, Santiago
Mojic, Marija K.
Steinborn, Dirk
Miljkovic, Djordje M.
Schmidt, Harry
Stosic-Grujicic, Stanislava D.
Sabo, Tibor
Maksimović-Ivanić, Danijela D.
Article (Published version)
Metadata
Show full item record
Abstract
Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
Source:
Metallomics, 2012, 4, 9, 979-987
Publisher:
  • Royal Soc Chemistry, Cambridge
Projects:
  • Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)
  • Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (RS-173013)
  • Alexander von Humboldt Foundation (Germany)

DOI: 10.1039/c2mt20058a

ISSN: 1756-5901

PubMed: 22820831

WoS: 000307903700013

Scopus: 2-s2.0-84865492745
[ Google Scholar ]
32
28
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1112
Collections
  • Radovi istraživača / Researchers' publications
Institution
IHTM

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

OpenAIRERCUB